Detailed information of TA system TA100448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1827334..1827893
• Replicon: chromosome
• Accession: NZ_CP028102
• Organism: Fusobacterium mortiferum ATCC 9817

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C4N19_RS09050
• Protein ID: WP_005885626.1
• Coordinates: 1827621..1827893 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C4N19_RS09045
• Protein ID: WP_005885408.1
• Coordinates: 1827334..1827615 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4N19_RS09015	1822757..1823197	-	441	WP_005885645.1	helix-turn-helix transcriptional regulator	-
C4N19_RS13525	1823500..1823637	+	138	WP_005885643.1	hypothetical protein	-
C4N19_RS09020	1823741..1824004	+	264	WP_005885639.1	hypothetical protein	-
C4N19_RS09025	1824155..1825252	+	1098	WP_005885637.1	YqaJ viral recombinase family protein	-
C4N19_RS09030	1825252..1825491	+	240	WP_005885634.1	hypothetical protein	-
C4N19_RS09035	1825491..1825928	+	438	WP_005885631.1	hypothetical protein	-
C4N19_RS09040	1825928..1826929	+	1002	WP_005885629.1	recombinase RecT	-
C4N19_RS09045	1827334..1827615	+	282	WP_005885408.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C4N19_RS09050	1827621..1827893	+	273	WP_005885626.1	type II toxin-antitoxin system YafQ family toxin	Toxin
C4N19_RS13415	1828041..1828217	+	177	WP_005885624.1	hypothetical protein	-
C4N19_RS09055	1828340..1829011	+	672	WP_005885622.1	Rha family transcriptional regulator	-
C4N19_RS09060	1829178..1829372	+	195	WP_005885620.1	hypothetical protein	-
C4N19_RS09065	1829372..1829626	+	255	WP_005885618.1	hypothetical protein	-
C4N19_RS09070	1829737..1829970	+	234	WP_005885615.1	hypothetical protein	-
C4N19_RS09075	1829971..1830396	+	426	WP_005885614.1	hypothetical protein	-
C4N19_RS09080	1830365..1830610	+	246	WP_005885613.1	hypothetical protein	-
C4N19_RS09085	1830804..1832198	+	1395	WP_005885610.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1786756..1832198	45442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10654.52 Da
• Isoelectric Point: 9.3103

>T100448 WP_005885626.1 NZ_CP028102:1827621-1827893 [Fusobacterium mortiferum ATCC 9817]
MLEIITTSAFDKDYKLLKKRGYNLKLLQEVVEKLANEEVLPAKYRNHQLIGNYIGYMECHIRPDWLLIYKIEKNKLILTL
SRTGTHSDLF

Nucleotide

• Length: 273 bp

>T100448 NZ_CP028102:1827621-1827893 [Fusobacterium mortiferum ATCC 9817]
ATGTTAGAAATCATAACTACTAGTGCTTTTGATAAAGATTATAAACTTTTAAAAAAAAGGGGATATAATCTCAAGCTTCT
TCAAGAAGTCGTTGAAAAATTAGCAAATGAAGAAGTGTTACCAGCTAAGTATAGAAATCATCAATTAATTGGAAATTATA
TAGGATACATGGAGTGCCATATTCGTCCTGATTGGTTATTAATATATAAAATTGAAAAAAATAAATTAATCCTAACTTTA
TCAAGAACAGGAACTCATAGTGATTTATTTTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10620.10 Da
• Isoelectric Point: 4.5498

>AT100448 WP_005885408.1 NZ_CP028102:1827334-1827615 [Fusobacterium mortiferum ATCC 9817]
MGVSVINVRLDDEDKKAFNELCNELGLNMSTAFNMFVKSMLRTGGLPFEARIENYNVETIKAIQETEDIINGKVKRPTYK
NTKELFDALDKED

Nucleotide

• Length: 282 bp

>AT100448 NZ_CP028102:1827334-1827615 [Fusobacterium mortiferum ATCC 9817]
ATGGGAGTATCAGTTATCAATGTAAGATTAGATGATGAAGATAAAAAAGCCTTTAATGAGTTATGTAATGAGTTAGGTTT
AAATATGTCAACAGCTTTTAATATGTTTGTCAAATCTATGCTTAGAACAGGTGGATTACCATTTGAGGCAAGAATAGAAA
ACTATAATGTTGAAACTATAAAAGCTATTCAAGAAACAGAAGATATTATCAATGGAAAAGTAAAACGTCCTACTTATAAA
AATACCAAAGAACTTTTTGATGCTCTTGATAAGGAGGATTAA