Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 837140..837632 Replicon chromosome
Accession NZ_CP028101
Organism Fusobacterium nucleatum subsp. nucleatum strain 25586

Toxin (Protein)


Gene name relE Uniprot ID A0A101K745
Locus tag C7Y58_RS04135 Protein ID WP_011016227.1
Coordinates 837366..837632 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A117MWN6
Locus tag C7Y58_RS04130 Protein ID WP_011016226.1
Coordinates 837140..837358 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7Y58_RS04110 832900..833697 + 798 WP_005902652.1 2-hydroxyglutaryl-CoA dehydratase -
C7Y58_RS04115 833760..835088 + 1329 WP_011016225.1 2-hydroxyacyl-CoA dehydratase subunit D -
C7Y58_RS04120 835110..836258 + 1149 WP_005902650.1 2-hydroxyacyl-CoA dehydratase subunit D -
C7Y58_RS04125 836269..836862 + 594 WP_005902649.1 leucine-rich repeat domain-containing protein -
C7Y58_RS04130 837140..837358 + 219 WP_011016226.1 CopG family transcriptional regulator Antitoxin
C7Y58_RS04135 837366..837632 + 267 WP_011016227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7Y58_RS04140 837675..838217 - 543 WP_011016228.1 hypothetical protein -
C7Y58_RS04145 838244..838750 - 507 WP_011016229.1 HAD family hydrolase -
C7Y58_RS04150 838760..839332 - 573 WP_005902123.1 crossover junction endodeoxyribonuclease RuvC -
C7Y58_RS04155 839332..840084 - 753 WP_005902124.1 MgtC/SapB family protein -
C7Y58_RS04160 840204..840956 - 753 WP_011016231.1 SDR family oxidoreductase -
C7Y58_RS04165 841144..841797 + 654 WP_011016232.1 Crp/Fnr family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(3-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10316.11 Da        Isoelectric Point: 10.1967

>T100447 WP_011016227.1 NZ_CP028101:837366-837632 [Fusobacterium nucleatum subsp. nucleatum]
MKYDVEYSKTAMNTIKKMDSSTSKLIRTWIEKNLINTENPRIKGKALTGDLKGLWRYRIGDYRILAEIQDDKIVILILDI
GHRSKIYL

Download         Length: 267 bp

>T100447 NZ_CP028101:837366-837632 [Fusobacterium nucleatum subsp. nucleatum]
ATGAAATATGATGTGGAATATTCTAAAACTGCTATGAATACCATAAAGAAAATGGATAGTTCAACTTCAAAGTTAATAAG
AACTTGGATAGAAAAAAATTTAATAAATACAGAAAATCCTAGAATAAAAGGAAAAGCATTAACTGGTGATTTAAAAGGAT
TATGGCGTTATAGAATAGGAGATTATAGAATATTAGCTGAAATTCAAGATGATAAAATAGTTATCTTAATCTTAGATATA
GGACATAGAAGTAAAATATATTTATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8461.57 Da        Isoelectric Point: 4.6535

>AT100447 WP_011016226.1 NZ_CP028101:837140-837358 [Fusobacterium nucleatum subsp. nucleatum]
MGTTATLRLDETEKAIIQDYASSKGMTMSEFVKRVVLDYIEDEYDLKIYKEYLKEKENGTLKTYSHKEVWGE

Download         Length: 219 bp

>AT100447 NZ_CP028101:837140-837358 [Fusobacterium nucleatum subsp. nucleatum]
ATGGGAACAACAGCAACATTAAGATTAGATGAAACAGAAAAAGCAATTATACAAGATTATGCAAGTAGTAAAGGAATGAC
TATGTCTGAATTTGTGAAAAGAGTAGTTCTTGATTATATTGAAGATGAATATGATTTAAAAATTTATAAAGAATATTTAA
AAGAAAAAGAAAATGGAACTTTAAAGACTTATTCACATAAAGAAGTTTGGGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A101K745

Antitoxin

Source ID Structure
AlphaFold DB A0A117MWN6

References