Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4639386..4640002 Replicon chromosome
Accession NZ_CP027986
Organism Enterobacter sichuanensis strain SGAir0282

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C1N69_RS22385 Protein ID WP_059386316.1
Coordinates 4639386..4639757 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C1N69_RS22390 Protein ID WP_059386317.1
Coordinates 4639760..4640002 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N69_RS22370 4636886..4637788 + 903 WP_025759554.1 formate dehydrogenase subunit beta -
C1N69_RS22375 4637785..4638420 + 636 WP_045285696.1 formate dehydrogenase cytochrome b556 subunit -
C1N69_RS22380 4638417..4639346 + 930 WP_025759557.1 formate dehydrogenase accessory protein FdhE -
C1N69_RS22385 4639386..4639757 - 372 WP_059386316.1 type II toxin-antitoxin system VapC family toxin Toxin
C1N69_RS22390 4639760..4640002 - 243 WP_059386317.1 ribbon-helix-helix protein, CopG family Antitoxin
C1N69_RS22395 4640252..4641193 - 942 WP_025759561.1 fatty acid biosynthesis protein FabY -
C1N69_RS22400 4641238..4641675 - 438 WP_008501836.1 D-tyrosyl-tRNA(Tyr) deacylase -
C1N69_RS22405 4641672..4642553 - 882 WP_045285692.1 virulence factor BrkB family protein -
C1N69_RS22410 4642547..4643146 - 600 WP_047959731.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13724.94 Da        Isoelectric Point: 6.8711

>T100434 WP_059386316.1 NZ_CP027986:c4639757-4639386 [Enterobacter sichuanensis]
MEHMAVFDTNILIDLFNNRVEAANTIESAASHRAISLITWMEVMVGARKYGHEAKTAALMGAFEIIEVNRDIAERSVMLR
ERHGMKLPDAIILATAQSRNCPLITRNTKDFQGIAGVVLPYQL

Download         Length: 372 bp

>T100434 NZ_CP027986:c4639757-4639386 [Enterobacter sichuanensis]
ATGGAACACATGGCGGTGTTTGATACCAATATCCTGATCGACCTTTTCAATAATCGTGTCGAGGCAGCAAATACAATCGA
AAGCGCTGCATCGCACCGAGCGATCAGTCTCATCACCTGGATGGAAGTCATGGTGGGGGCACGCAAGTATGGCCATGAAG
CGAAAACAGCGGCGTTAATGGGCGCTTTTGAGATTATTGAGGTAAACCGAGATATCGCAGAAAGAAGCGTAATGCTCCGC
GAGCGGCATGGCATGAAGCTTCCGGATGCCATTATTTTAGCGACGGCTCAAAGCAGAAATTGCCCGTTAATCACTCGGAA
TACCAAAGACTTTCAGGGGATCGCCGGAGTAGTTTTACCTTATCAACTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9454.66 Da        Isoelectric Point: 4.2584

>AT100434 WP_059386317.1 NZ_CP027986:c4640002-4639760 [Enterobacter sichuanensis]
MSLLAELNMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIEQYLDQQSSSIIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT100434 NZ_CP027986:c4640002-4639760 [Enterobacter sichuanensis]
ATGAGTTTGCTGGCGGAGCTTAACATGGGCAGGATCCTGATCGATTTGTCGGATGACGTTATTCAGCGTCTCGATAACCT
CAAACAGCTACGTAACCAACCTCGTGCCGAATTACTGCGTGAAGCAATTGAGCAGTATCTCGACCAGCAGAGTTCTTCGA
TTATTCGCGATGCGCTTGGCTTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGTAAGTTGCGTGAGGAGTGG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References