Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3849071..3849728 Replicon chromosome
Accession NZ_CP027986
Organism Enterobacter sichuanensis strain SGAir0282

Toxin (Protein)


Gene name cptA Uniprot ID A0A0F1AZ23
Locus tag C1N69_RS18585 Protein ID WP_025757758.1
Coordinates 3849071..3849481 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F1AVN1
Locus tag C1N69_RS18590 Protein ID WP_025757757.1
Coordinates 3849462..3849728 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N69_RS18565 3845064..3846797 - 1734 WP_155031679.1 single-stranded-DNA-specific exonuclease RecJ -
C1N69_RS18570 3846803..3847516 - 714 WP_047959419.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C1N69_RS18575 3847545..3848441 - 897 WP_028016949.1 site-specific tyrosine recombinase XerD -
C1N69_RS18580 3848543..3849064 + 522 WP_008499710.1 flavodoxin FldB -
C1N69_RS18585 3849071..3849481 - 411 WP_025757758.1 protein YgfX Toxin
C1N69_RS18590 3849462..3849728 - 267 WP_025757757.1 FAD assembly factor SdhE Antitoxin
C1N69_RS18595 3850023..3851003 + 981 WP_025757755.1 tRNA-modifying protein YgfZ -
C1N69_RS18600 3851088..3851747 - 660 WP_025757753.1 hemolysin III family protein -
C1N69_RS18605 3852013..3852744 + 732 WP_025757752.1 MurR/RpiR family transcriptional regulator -
C1N69_RS18610 3852861..3854294 + 1434 WP_128339439.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16047.99 Da        Isoelectric Point: 11.1910

>T100433 WP_025757758.1 NZ_CP027986:c3849481-3849071 [Enterobacter sichuanensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGT
EWDILGMPWMLNTGMMLRLRKVEGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T100433 NZ_CP027986:c3849481-3849071 [Enterobacter sichuanensis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCATGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTTGCGGC
CATTGTGCTGCTGATGCCATGGCCGCTGAGCTACACGCCGCTGTGGCTGCTGCTACTGTCGTTTGTTGTATTTGACAGCG
TACGCAGCCAGCGTCGCATCAATGCCCGTCAGGGAGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAACA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAATACCGGCATGATGTTACGGTTACGCAAGGTAGAAGGCGGACGTTG
CCAGCATCTGTGGCTGGCCGCTGACAGTATGGATGCGGCCGAGTGGCGAGACCTGCGCCGTATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.00 Da        Isoelectric Point: 5.1296

>AT100433 WP_025757757.1 NZ_CP027986:c3849728-3849462 [Enterobacter sichuanensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKHLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT100433 NZ_CP027986:c3849728-3849462 [Enterobacter sichuanensis]
ATGGATATTAACAACAAGGCCCGTATCCACTGGGCGTGTCGTCGCGGCATGCGTGAGCTTGATATTTCCATCATGCCTTT
CTTTGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCATCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1AZ23

Antitoxin

Source ID Structure
AlphaFold DB A0A0F1AVN1

References