Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1098823..1099449 Replicon chromosome
Accession NZ_CP027986
Organism Enterobacter sichuanensis strain SGAir0282

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag C1N69_RS05095 Protein ID WP_008499287.1
Coordinates 1098823..1099041 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag C1N69_RS05100 Protein ID WP_008499288.1
Coordinates 1099075..1099449 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N69_RS05065 1094835..1095095 + 261 WP_047957896.1 type B 50S ribosomal protein L31 -
C1N69_RS05070 1095098..1095238 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
C1N69_RS05075 1095235..1095945 - 711 WP_047957897.1 GNAT family N-acetyltransferase -
C1N69_RS05080 1096047..1097507 + 1461 WP_155030782.1 PLP-dependent aminotransferase family protein -
C1N69_RS05085 1097479..1097946 - 468 WP_059385616.1 hypothetical protein -
C1N69_RS05090 1098063..1098614 - 552 WP_059385617.1 maltose O-acetyltransferase -
C1N69_RS05095 1098823..1099041 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
C1N69_RS05100 1099075..1099449 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
C1N69_RS05105 1099962..1103108 - 3147 WP_047957901.1 multidrug efflux RND transporter permease subunit AcrB -
C1N69_RS05110 1103131..1104324 - 1194 WP_047957902.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T100423 WP_008499287.1 NZ_CP027986:c1099041-1098823 [Enterobacter sichuanensis]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T100423 NZ_CP027986:c1099041-1098823 [Enterobacter sichuanensis]
ATGTCTGATAAACCACTCACTAAGATCGATTATTTGATGCGCCTGCGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCGGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT100423 WP_008499288.1 NZ_CP027986:c1099449-1099075 [Enterobacter sichuanensis]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT100423 NZ_CP027986:c1099449-1099075 [Enterobacter sichuanensis]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References