Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 55677..56339 Replicon chromosome
Accession NZ_CP027986
Organism Enterobacter sichuanensis strain SGAir0282

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C1N69_RS00280 Protein ID WP_179958047.1
Coordinates 55941..56339 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C1N69_RS00275 Protein ID WP_155030496.1
Coordinates 55677..55937 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N69_RS00260 53102..54223 - 1122 WP_155030493.1 efflux RND transporter periplasmic adaptor subunit -
C1N69_RS00265 54372..54941 - 570 WP_155030494.1 TetR/AcrR family transcriptional regulator -
C1N69_RS00270 55128..55547 + 420 WP_155030495.1 GNAT family N-acetyltransferase -
C1N69_RS00275 55677..55937 + 261 WP_155030496.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C1N69_RS00280 55941..56339 + 399 WP_179958047.1 type II toxin-antitoxin system VapC family toxin Toxin
C1N69_RS00285 56461..57279 + 819 WP_176472031.1 lipoprotein NlpA -
C1N69_RS00290 57401..58180 + 780 WP_095441455.1 MBL fold metallo-hydrolase -
C1N69_RS00295 58207..59166 + 960 WP_095452049.1 helix-turn-helix domain-containing protein -
C1N69_RS00300 59590..60678 - 1089 WP_104556750.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14720.93 Da        Isoelectric Point: 6.3267

>T100420 WP_179958047.1 NZ_CP027986:55941-56339 [Enterobacter sichuanensis]
MLHMLDTNIVSHLVRQHPGVIKQYSRTPTEKMCISSVTEAELLYGIAKKQSDTLQKTILEFLKTITICDWDSEAAATYGE
LRAAMEKRGKVMGDLDQLIAAHAISRGTTIVTNDHAFRMVQELAVEDWTAAS

Download         Length: 399 bp

>T100420 NZ_CP027986:55941-56339 [Enterobacter sichuanensis]
ATGCTGCATATGTTGGACACAAACATAGTAAGCCACCTCGTAAGGCAACATCCCGGGGTGATAAAACAATATTCTCGCAC
CCCAACAGAAAAAATGTGTATTTCAAGCGTGACGGAGGCCGAACTGCTTTATGGCATAGCCAAAAAGCAAAGTGACACAT
TACAAAAAACCATACTTGAGTTCCTTAAAACCATCACTATCTGCGACTGGGACAGTGAAGCCGCAGCAACGTACGGTGAA
CTCCGCGCAGCAATGGAGAAGAGAGGAAAAGTGATGGGCGATCTCGATCAGCTGATCGCTGCGCATGCTATTAGTCGGGG
TACAACGATAGTGACTAACGATCATGCGTTCAGAATGGTGCAGGAGCTTGCCGTCGAGGACTGGACGGCAGCGTCGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10206.46 Da        Isoelectric Point: 8.5750

>AT100420 WP_155030496.1 NZ_CP027986:55677-55937 [Enterobacter sichuanensis]
MERTAKLFKKGRNQAVMLPAEFTFDTESVYIRRDEEGNVVLTARSEKERHRDNFLRLLKQTHVPDSFLSKEERNQSYTTR
DPFEGL

Download         Length: 261 bp

>AT100420 NZ_CP027986:55677-55937 [Enterobacter sichuanensis]
ATGGAACGTACAGCAAAACTCTTCAAAAAGGGGCGAAATCAGGCAGTGATGCTGCCTGCTGAATTCACGTTTGATACAGA
GAGCGTTTATATCCGACGAGATGAGGAAGGGAATGTCGTTTTGACTGCGAGATCGGAAAAGGAGCGTCACAGAGATAACT
TTTTACGTTTATTGAAGCAGACTCATGTTCCTGATTCATTTCTGAGCAAAGAGGAACGTAATCAGAGCTATACAACAAGA
GATCCATTTGAAGGGCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References