Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 25844..26403 | Replicon | plasmid pCRKP18622-KPC |
| Accession | NZ_CP027866 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain CRKP18622 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1PMX5 |
| Locus tag | C7K64_RS27855 | Protein ID | WP_000421257.1 |
| Coordinates | 25844..26119 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | C1J8K5 |
| Locus tag | C7K64_RS27860 | Protein ID | WP_001178089.1 |
| Coordinates | 26119..26403 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C7K64_RS27815 (21017) | 21017..21206 | - | 190 | Protein_24 | Tn3 family transposase | - |
| C7K64_RS27820 (21536) | 21536..22396 | - | 861 | WP_000027057.1 | broad-spectrum class A beta-lactamase TEM-1 | - |
| C7K64_RS27825 (22579) | 22579..22977 | - | 399 | Protein_26 | recombinase family protein | - |
| C7K64_RS27830 (23040) | 23040..23744 | + | 705 | WP_001067845.1 | IS6-like element IS26 family transposase | - |
| C7K64_RS27835 (23831) | 23831..24178 | - | 348 | WP_000142451.1 | DUF6404 family protein | - |
| C7K64_RS27840 (24307) | 24307..24642 | + | 336 | WP_001080730.1 | colicin 1A immunity protein | - |
| C7K64_RS27845 (24664) | 24664..25032 | - | 369 | Protein_30 | colicin-like pore-forming protein | - |
| C7K64_RS27850 (25097) | 25097..25794 | + | 698 | WP_095033700.1 | IS1-like element IS1B family transposase | - |
| C7K64_RS27855 (25844) | 25844..26119 | - | 276 | WP_000421257.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| C7K64_RS27860 (26119) | 26119..26403 | - | 285 | WP_001178089.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| C7K64_RS27865 (26914) | 26914..27618 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| C7K64_RS27870 (28024) | 28024..28641 | + | 618 | Protein_35 | replication protein | - |
| C7K64_RS27875 (29175) | 29175..29453 | + | 279 | WP_013213990.1 | hypothetical protein | - |
| C7K64_RS27880 (29564) | 29564..29989 | + | 426 | WP_013213989.1 | antirestriction protein | - |
| C7K64_RS27885 (30117) | 30117..30272 | + | 156 | WP_013213988.1 | hypothetical protein | - |
| C7K64_RS27890 (30318) | 30318..30614 | + | 297 | WP_013213987.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | cmlA1 / qacE / blaCTX-M-14 / blaTEM-1B / blaKPC-2 / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..134794 | 134794 | |
| - | inside | IScluster/Tn | cmlA1 / qacE / blaCTX-M-14 / blaTEM-1B / blaKPC-2 | - | 592..37984 | 37392 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10749.45 Da Isoelectric Point: 9.9324
>T100407 WP_000421257.1 NZ_CP027866:c26119-25844 [Klebsiella pneumoniae subsp. pneumoniae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T100407 NZ_CP027866:c26119-25844 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10474.89 Da Isoelectric Point: 5.6558
>AT100407 WP_001178089.1 NZ_CP027866:c26403-26119 [Klebsiella pneumoniae subsp. pneumoniae]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
Download Length: 285 bp
>AT100407 NZ_CP027866:c26403-26119 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1PMX5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A731IHA8 |