Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4920137..4920653 Replicon chromosome
Accession NZ_CP027863
Organism Klebsiella pneumoniae subsp. pneumoniae strain CRKP18622

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag C7K64_RS23775 Protein ID WP_004178374.1
Coordinates 4920137..4920421 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C7K64_RS23780 Protein ID WP_002886901.1
Coordinates 4920411..4920653 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7K64_RS23750 (4915533) 4915533..4915796 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
C7K64_RS23755 (4915926) 4915926..4916099 + 174 WP_041169004.1 hypothetical protein -
C7K64_RS23760 (4916102) 4916102..4916845 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C7K64_RS23765 (4917202) 4917202..4919340 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
C7K64_RS23770 (4919669) 4919669..4920133 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C7K64_RS23775 (4920137) 4920137..4920421 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7K64_RS23780 (4920411) 4920411..4920653 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C7K64_RS23785 (4920731) 4920731..4922641 - 1911 WP_012737231.1 PRD domain-containing protein -
C7K64_RS23790 (4922664) 4922664..4923818 - 1155 WP_012737230.1 lactonase family protein -
C7K64_RS23795 (4923885) 4923885..4924625 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T100404 WP_004178374.1 NZ_CP027863:c4920421-4920137 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T100404 NZ_CP027863:c4920421-4920137 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT100404 WP_002886901.1 NZ_CP027863:c4920653-4920411 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT100404 NZ_CP027863:c4920653-4920411 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References