Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 3417596..3418257 Replicon chromosome
Accession NZ_CP027862
Organism Actinomyces sp. Z16

Toxin (Protein)


Gene name vapC Uniprot ID A0A1M4S0P1
Locus tag C3B71_RS14155 Protein ID WP_073331135.1
Coordinates 3417596..3418021 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1M4S0R7
Locus tag C3B71_RS14160 Protein ID WP_073331139.1
Coordinates 3418018..3418257 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3B71_RS14140 3414770..3416107 - 1338 WP_073331127.1 NADP-specific glutamate dehydrogenase -
C3B71_RS14145 3416328..3416765 - 438 WP_073331129.1 cupin domain-containing protein -
C3B71_RS16215 3416984..3417535 + 552 WP_181574819.1 hypothetical protein -
C3B71_RS14155 3417596..3418021 - 426 WP_073331135.1 type II toxin-antitoxin system VapC family toxin Toxin
C3B71_RS14160 3418018..3418257 - 240 WP_073331139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C3B71_RS14165 3418349..3419719 - 1371 WP_108968906.1 GntP family transporter -
C3B71_RS14170 3419730..3420617 - 888 WP_108968908.1 NAD(P)-dependent oxidoreductase -
C3B71_RS14175 3420709..3422127 - 1419 WP_108968911.1 hypothetical protein -
C3B71_RS14180 3422223..3422915 - 693 WP_108968913.1 FadR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

SpoVT-AbrB domain

(4-42)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14467.43 Da        Isoelectric Point: 6.8808

>T100389 WP_073331135.1 NZ_CP027862:c3418021-3417596 [Actinomyces sp. Z16]
VNAAPRLAVDTSVAIPLLVASHEAHRPVRDWARGRRLSLSGHALAETYAVLTRLPGDARVSAEDAVALIDDRFPEVLALS
ANSAITAHRRLAGLGIAGGAVYDGLVALAALENGAVLATRDARARGTYEAVGVAVEAVTAG

Download         Length: 426 bp

>T100389 NZ_CP027862:c3418021-3417596 [Actinomyces sp. Z16]
GTGAACGCCGCGCCGCGCCTAGCCGTCGACACGAGTGTTGCCATTCCTCTGCTGGTCGCCTCCCATGAGGCACATCGCCC
GGTGCGTGACTGGGCGAGGGGGAGGCGGCTGAGTCTCAGCGGGCACGCCCTGGCGGAGACCTATGCGGTGCTGACGCGGC
TCCCCGGAGACGCGCGCGTGTCCGCCGAAGACGCGGTTGCGCTTATCGACGACCGTTTCCCAGAGGTACTCGCCCTTTCT
GCGAATTCGGCGATCACGGCACACCGGCGATTGGCCGGCCTTGGAATCGCCGGCGGTGCCGTCTACGACGGTCTGGTCGC
TCTCGCGGCGTTGGAGAATGGCGCGGTGCTCGCCACACGGGACGCGCGCGCGAGGGGGACATATGAAGCGGTCGGAGTCG
CCGTCGAGGCAGTCACGGCCGGATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8289.43 Da        Isoelectric Point: 5.7631

>AT100389 WP_073331139.1 NZ_CP027862:c3418257-3418018 [Actinomyces sp. Z16]
MELTIDSGGRILLPKSLRESLGLLPGTKVDVSPYGGGVQLTPGGRTARVERGEDGHLVATSQTPVTDDVMFALIDGGRR

Download         Length: 240 bp

>AT100389 NZ_CP027862:c3418257-3418018 [Actinomyces sp. Z16]
ATGGAGCTGACGATCGATTCGGGCGGACGCATCCTCCTGCCGAAGAGCCTGCGGGAGTCGCTTGGATTGCTGCCGGGAAC
GAAGGTGGATGTGTCCCCCTATGGAGGCGGCGTGCAGCTGACCCCGGGTGGGCGTACTGCCCGAGTGGAGCGTGGTGAGG
ATGGGCACCTGGTCGCCACTTCGCAGACCCCAGTCACCGATGACGTGATGTTCGCACTGATCGATGGTGGCAGAAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4S0P1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4S0R7

References