Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1809985..1810520 Replicon chromosome
Accession NZ_CP027862
Organism Actinomyces sp. Z16

Toxin (Protein)


Gene name relE Uniprot ID A0A1M4S1L0
Locus tag C3B71_RS07520 Protein ID WP_073332200.1
Coordinates 1809985..1810245 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1M4S1M0
Locus tag C3B71_RS07525 Protein ID WP_073332197.1
Coordinates 1810257..1810520 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3B71_RS07495 1805770..1807251 - 1482 WP_073332215.1 sodium/proline symporter PutP -
C3B71_RS07500 1807259..1807678 - 420 WP_108967120.1 dihydroxyacetone kinase -
C3B71_RS07505 1807675..1808355 - 681 WP_108967122.1 dihydroxyacetone kinase subunit L -
C3B71_RS07510 1808361..1809362 - 1002 WP_108967124.1 dihydroxyacetone kinase subunit DhaK -
C3B71_RS07515 1809462..1809995 - 534 WP_108967126.1 holo-ACP synthase -
C3B71_RS07520 1809985..1810245 - 261 WP_073332200.1 Txe/YoeB family addiction module toxin Toxin
C3B71_RS07525 1810257..1810520 - 264 WP_073332197.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10344.78 Da        Isoelectric Point: 9.5952

>T100386 WP_073332200.1 NZ_CP027862:c1810245-1809985 [Actinomyces sp. Z16]
MRLIWSTHAWEDYLWWQTEDRRVLKRVNLLLQDIQRHGNEGLGKPEALRGNLSGYWSRRITSEHRLVYRVDGDDVLIVAC
RLHYGR

Download         Length: 261 bp

>T100386 NZ_CP027862:c1810245-1809985 [Actinomyces sp. Z16]
ATGAGACTCATCTGGTCTACCCACGCCTGGGAGGACTACCTGTGGTGGCAGACTGAGGATCGTCGAGTCCTCAAACGCGT
CAATCTCCTCCTCCAGGACATCCAACGACACGGCAACGAGGGTCTCGGCAAGCCAGAGGCCCTCCGCGGCAATCTCAGCG
GCTACTGGTCGCGTCGCATCACGTCCGAGCACAGGCTCGTCTACCGGGTCGATGGGGACGACGTCCTCATCGTTGCGTGC
AGGCTCCACTATGGGCGTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9798.90 Da        Isoelectric Point: 4.5562

>AT100386 WP_073332197.1 NZ_CP027862:c1810520-1810257 [Actinomyces sp. Z16]
MRTMTYTESRARYAQVLNDVVDDREEVVITRAGHDPAVIVSLAEYEALKETAYLLRNPANARRLLESITELEDGHGKAHE
LVNTGED

Download         Length: 264 bp

>AT100386 NZ_CP027862:c1810520-1810257 [Actinomyces sp. Z16]
ATGAGGACCATGACCTACACGGAGTCCCGCGCGCGCTACGCCCAAGTGCTCAATGACGTCGTGGACGACCGCGAGGAGGT
CGTCATCACCCGAGCCGGGCATGATCCTGCCGTCATCGTCTCCCTAGCGGAGTATGAGGCGCTCAAGGAGACCGCTTATC
TCCTGCGCAACCCCGCCAACGCCAGGCGGCTCCTGGAGTCGATCACCGAGCTCGAGGACGGGCACGGCAAGGCCCACGAG
CTGGTGAACACCGGTGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4S1L0

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4S1M0

References