Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143085..143590 Replicon chromosome
Accession NZ_CP027857
Organism Pseudomonas aeruginosa strain MPAO1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag MPAO1_RS00660 Protein ID WP_003083773.1
Coordinates 143085..143366 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag MPAO1_RS00665 Protein ID WP_003112628.1
Coordinates 143363..143590 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPAO1_RS00635 138336..139685 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
MPAO1_RS00640 139734..140420 + 687 WP_003083762.1 FadR family transcriptional regulator -
MPAO1_RS00645 140521..141255 + 735 WP_003115036.1 GntR family transcriptional regulator -
MPAO1_RS00650 141459..141845 + 387 WP_014602345.1 aegerolysin family protein -
MPAO1_RS00655 141877..142785 - 909 WP_003083769.1 LysR family transcriptional regulator -
MPAO1_RS00660 143085..143366 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
MPAO1_RS00665 143363..143590 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
MPAO1_RS00670 143766..144386 - 621 WP_003101226.1 hypothetical protein -
MPAO1_RS00675 144487..144987 + 501 WP_003112629.1 LEA type 2 family protein -
MPAO1_RS00680 145060..145401 + 342 WP_003101229.1 alkylphosphonate utilization protein -
MPAO1_RS00685 145483..146910 - 1428 WP_003083784.1 GABA permease -
MPAO1_RS00690 147079..148572 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T100376 WP_003083773.1 NZ_CP027857:c143366-143085 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T100376 NZ_CP027857:c143366-143085 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT100376 WP_003112628.1 NZ_CP027857:c143590-143363 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT100376 NZ_CP027857:c143590-143363 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References