Detailed information of TA system TA100374

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 3739451..3739992
• Replicon: chromosome
• Accession: NZ_CP027850
• Organism: Caulobacter segnis strain TK0059

Toxin (Protein)

• Gene name: parE
• Uniprot ID: D5VMX2
• Locus tag: B7G68_RS17490
• Protein ID: WP_013080492.1
• Coordinates: 3739699..3739992 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D5VMX1
• Locus tag: B7G68_RS17485
• Protein ID: WP_013080491.1
• Coordinates: 3739451..3739702 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7G68_RS17460	3734880..3735482	-	603	WP_013080488.1	DUF4893 domain-containing protein	-
B7G68_RS17465	3735559..3735894	-	336	WP_083778494.1	response regulator	-
B7G68_RS17470	3735905..3736957	-	1053	WP_041538355.1	PAS domain S-box protein	-
B7G68_RS17475	3737129..3738247	-	1119	WP_013080489.1	DUF4167 domain-containing protein	-
B7G68_RS17480	3738493..3739362	-	870	WP_013080490.1	peptide chain release factor N(5)-glutamine methyltransferase	-
B7G68_RS17485	3739451..3739702	+	252	WP_013080491.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
B7G68_RS17490	3739699..3739992	+	294	WP_013080492.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B7G68_RS17495	3739984..3740745	-	762	WP_013080493.1	MOSC domain-containing protein	-
B7G68_RS17500	3740849..3742060	+	1212	WP_013080494.1	YihY/virulence factor BrkB family protein	-
B7G68_RS17505	3742057..3742587	-	531	WP_013080495.1	methyltransferase domain-containing protein	-
B7G68_RS17510	3742671..3743198	+	528	WP_013080496.1	GNAT family N-acetyltransferase	-
B7G68_RS17515	3743335..3744111	+	777	WP_013080497.1	hypothetical protein	-
B7G68_RS17520	3744121..3744241	+	121	Protein_3437	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11476.18 Da
• Isoelectric Point: 8.0351

>T100374 WP_013080492.1 NZ_CP027850:3739699-3739992 [Caulobacter segnis]
VSHYELTPLARFDMREIWTYTVRQWGRRVADGYIRDLSTTLEKIAREPYVGVAAEWIEEDCRKYVFRSHVIFYTPMKEGV
VVARILHQQMDAPSRLG

Nucleotide

• Length: 294 bp

>T100374 NZ_CP027850:3739699-3739992 [Caulobacter segnis]
GTGAGCCACTATGAGCTGACGCCGCTAGCGCGCTTCGATATGCGCGAAATCTGGACCTACACCGTTCGTCAATGGGGCCG
AAGGGTCGCCGACGGCTACATTCGCGACCTGTCCACCACGCTCGAAAAGATCGCCCGTGAACCTTACGTCGGCGTCGCTG
CGGAATGGATCGAAGAGGACTGCCGAAAGTACGTCTTTCGGTCCCACGTCATCTTCTATACGCCGATGAAGGAAGGTGTG
GTCGTCGCCCGTATACTCCATCAACAGATGGATGCACCAAGCCGCCTAGGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9252.20 Da
• Isoelectric Point: 4.3992

>AT100374 WP_013080491.1 NZ_CP027850:3739451-3739702 [Caulobacter segnis]
MSKNTSIVLSEHFQSFITEKVEEGRYGSASEVVRAGLRLLEDHEAKLTALRTAVREGFESGKPEPFDVDTFLAEVNTDYD
AQS

Nucleotide

• Length: 252 bp

>AT100374 NZ_CP027850:3739451-3739702 [Caulobacter segnis]
ATGAGCAAGAACACCTCGATCGTCCTTAGTGAGCATTTTCAGTCCTTCATCACGGAGAAGGTCGAAGAGGGACGATATGG
CTCGGCGAGCGAGGTCGTTCGCGCCGGACTACGCCTGCTGGAGGATCACGAAGCCAAGCTCACGGCGCTCCGGACCGCCG
TGAGGGAAGGCTTTGAGAGCGGCAAGCCCGAGCCGTTCGATGTCGACACCTTCCTCGCGGAGGTCAACACGGACTACGAC
GCCCAGTCGTGA

Structures

Toxin

• AlphaFold DB: D5VMX2

Antitoxin

• AlphaFold DB: D5VMX1