Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 953517..954039 Replicon chromosome
Accession NZ_CP027848
Organism Staphylococcus muscae strain ATCC 49910

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag C7J88_RS04720 Protein ID WP_095117495.1
Coordinates 953517..953738 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag C7J88_RS04725 Protein ID WP_095117496.1
Coordinates 953752..954039 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7J88_RS04705 949526..950731 + 1206 WP_095117493.1 rod shape-determining protein RodA -
C7J88_RS10420 950802..950963 - 162 WP_157728697.1 hypothetical protein -
C7J88_RS04710 951028..953211 - 2184 WP_095118146.1 heavy metal translocating P-type ATPase -
C7J88_RS04715 953311..953514 - 204 WP_095117494.1 cation transporter -
C7J88_RS04720 953517..953738 - 222 WP_095117495.1 heavy-metal-associated domain-containing protein Toxin
C7J88_RS04725 953752..954039 - 288 WP_095117496.1 copper-sensing transcriptional repressor CsoR Antitoxin
C7J88_RS04730 954183..955673 + 1491 WP_095117497.1 cardiolipin synthase -
C7J88_RS04735 955694..956332 + 639 WP_095117498.1 HD domain-containing protein -
C7J88_RS04740 956401..957270 - 870 WP_095117499.1 membrane protein insertase YidC -
C7J88_RS04745 957359..957997 - 639 WP_095118147.1 thiamine phosphate synthase -
C7J88_RS04750 957987..958793 - 807 WP_095117500.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(5-63)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8234.21 Da        Isoelectric Point: 4.5284

>T100373 WP_095117495.1 NZ_CP027848:c953738-953517 [Staphylococcus muscae]
VHSKVWLSGLSSEEQKKQLESRLSNMIGVEAVEVNTESQMVTLTYETPANLNTLEKEIYDAGYPVINSYKGER

Download         Length: 222 bp

>T100373 NZ_CP027848:c953738-953517 [Staphylococcus muscae]
GTGCATAGTAAAGTATGGCTATCTGGTCTCTCGAGTGAGGAACAGAAGAAACAGCTTGAGTCGAGACTGAGCAATATGAT
TGGTGTTGAAGCGGTAGAAGTGAATACCGAATCACAAATGGTGACACTGACGTATGAAACACCAGCTAACTTGAATACGT
TGGAAAAAGAAATTTATGATGCAGGTTATCCTGTCATCAATTCATATAAAGGAGAGCGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10900.45 Da        Isoelectric Point: 6.7505

>AT100373 WP_095117496.1 NZ_CP027848:c954039-953752 [Staphylococcus muscae]
MTEHANHSDVTKRNLQSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNGVASKLLEHHMKGCIMHKVEGGNEHE
AMDELLVTFQKLMKD

Download         Length: 288 bp

>AT100373 NZ_CP027848:c954039-953752 [Staphylococcus muscae]
ATGACAGAACATGCAAATCATTCTGACGTGACGAAACGCAATTTACAATCTCGTTTAAATCGCATTGAAGGACAAGTACG
AGCAATTAATCGTATGATTGAAGAAGACGTCTATTGCGATGATGTTCTGACTCAAATCCGTGCAACACGTTCTGCGCTGA
ATGGTGTGGCATCCAAGTTGTTAGAACACCATATGAAAGGATGTATCATGCACAAAGTAGAAGGTGGCAATGAACATGAA
GCGATGGATGAACTACTCGTGACCTTCCAAAAGTTGATGAAAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References