Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 939506..940030 Replicon chromosome
Accession NZ_CP027848
Organism Staphylococcus muscae strain ATCC 49910

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C7J88_RS04650 Protein ID WP_095117482.1
Coordinates 939506..939859 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C7J88_RS04655 Protein ID WP_095117483.1
Coordinates 939860..940030 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7J88_RS04630 936575..937348 - 774 WP_095117478.1 RNA polymerase sigma factor SigB -
C7J88_RS04635 937320..937802 - 483 WP_095117479.1 anti-sigma B factor RsbW -
C7J88_RS04640 937804..938130 - 327 WP_095117480.1 anti-sigma factor antagonist -
C7J88_RS04645 938206..939234 - 1029 WP_095117481.1 PP2C family protein-serine/threonine phosphatase -
C7J88_RS04650 939506..939859 - 354 WP_095117482.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C7J88_RS04655 939860..940030 - 171 WP_095117483.1 antitoxin MazE Antitoxin
C7J88_RS04660 940119..941267 - 1149 WP_095117484.1 alanine racemase -
C7J88_RS04665 941295..941654 - 360 WP_095117485.1 holo-ACP synthase -
C7J88_RS04670 941651..942226 - 576 WP_095117486.1 PH domain-containing protein -
C7J88_RS04675 942216..943721 - 1506 WP_095117487.1 PH domain-containing protein -
C7J88_RS04680 943714..944187 - 474 WP_095117488.1 PH domain-containing protein -
C7J88_RS04685 944322..945023 - 702 WP_095117489.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13030.17 Da        Isoelectric Point: 10.2682

>T100372 WP_095117482.1 NZ_CP027848:c939859-939506 [Staphylococcus muscae]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKNRLKEKLTFLSDEKMKEVNNALGISLGLQVVQSR

Download         Length: 354 bp

>T100372 NZ_CP027848:c939859-939506 [Staphylococcus muscae]
ATGAAGCGCGGTGATGTATACTTAGCTGATTTATCACCAGTACAGGGTTCTGAACAAGGGGGAGTTAGACCCGTCGTAAT
CATACAAAATGATACTGGTAACAAATATAGTCCGACTGTGATTGTAGCGGCAATTACTGGACGTATTAATAAAGCGAAGA
TTCCAACACATGTAGAAATTGAAAAAAAGAAATACAAACTGGACAAAGATTCTGTTATTTTGTTAGAACAGATTCGGACA
GTTGATAAAAATCGATTGAAAGAAAAACTGACTTTTTTATCGGACGAAAAGATGAAAGAAGTAAACAATGCACTCGGTAT
CAGTCTAGGGTTACAAGTGGTTCAATCACGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.02 Da        Isoelectric Point: 4.2313

>AT100372 WP_095117483.1 NZ_CP027848:c940030-939860 [Staphylococcus muscae]
MSVFNQVKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSKHQDD

Download         Length: 171 bp

>AT100372 NZ_CP027848:c940030-939860 [Staphylococcus muscae]
ATGTCAGTATTCAATCAAGTAAAATTTAAAAATTTAGAGCAGTCATTAAAAGAAGGTTATGCACAAATGGCTGATCTCAA
TCTCTCCCTAGCGACAGAAGCATATTCAGTAGAGTGTGAGGCGTGCGATTGTAATGAATCTCACTTACTATCAAAGCATC
AGGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References