Detailed information of TA system TA100371

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 791484..792260
• Replicon: chromosome
• Accession: NZ_CP027848
• Organism: Staphylococcus muscae strain ATCC 49910

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: C7J88_RS10520
• Protein ID: WP_169712259.1
• Coordinates: 791484..791642 (-)
• Length: 53 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: C7J88_RS03820
• Protein ID: WP_095117350.1
• Coordinates: 791661..792260 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7J88_RS03805	787761..789287	-	1527	WP_095117347.1	exopolyphosphatase	-
C7J88_RS03810	789309..790694	-	1386	WP_095117348.1	class II fumarate hydratase	-
C7J88_RS03815	790874..791278	-	405	WP_095117349.1	hypothetical protein	-
C7J88_RS10520	791484..791642	-	159	WP_169712259.1	hypothetical protein	Toxin
C7J88_RS03820	791661..792260	-	600	WP_095117350.1	glucosamine-6-phosphate isomerase	Antitoxin
C7J88_RS03825	792284..793459	-	1176	WP_095117351.1	N-acetylglucosamine-6-phosphate deacetylase	-
C7J88_RS03830	793480..793950	-	471	WP_095117352.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
C7J88_RS03835	793950..795080	-	1131	WP_095117353.1	tRNA epoxyqueuosine(34) reductase QueG	-
C7J88_RS03840	795239..795961	-	723	WP_095117354.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6211.59 Da
• Isoelectric Point: 3.9861

>T100371 WP_169712259.1 NZ_CP027848:c791642-791484 [Staphylococcus muscae]
MNKQENEHGMVDSFEEVVELGKEMEQISEENDEQKYEQPHEEAVRSDRETDK

Nucleotide

• Length: 159 bp

>T100371 NZ_CP027848:c791642-791484 [Staphylococcus muscae]
ATGAATAAACAAGAAAATGAACATGGCATGGTTGACAGCTTTGAAGAAGTTGTTGAGTTAGGAAAAGAGATGGAACAAAT
CTCTGAAGAAAACGATGAACAAAAATATGAACAACCACATGAAGAAGCGGTTCGTAGTGATCGCGAAACAGATAAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22242.24 Da
• Isoelectric Point: 5.6169

>AT100371 WP_095117350.1 NZ_CP027848:c792260-791661 [Staphylococcus muscae]
MAMNFKIFKDQETAATFVADILRKQFNNNPTTIAGIHLKNDNVPVSAALQENVEKNPVDFSQIHILDYDNQTNYYKALGV
PEKQIHEIPEDEKVEAFIKHHAKTKENKGKLTLQVVTIDTDGSIGIPMNDAVLTAREIVLVLTGAEKAEVTRKLYEENGS
TTFIPSSLKSHRMVNVVLDEAAAQGLPEDVRTYFSVRFA

Nucleotide

• Length: 600 bp

>AT100371 NZ_CP027848:c792260-791661 [Staphylococcus muscae]
ATGGCAATGAACTTTAAAATTTTCAAGGATCAAGAAACGGCTGCAACGTTTGTAGCGGATATTTTAAGAAAGCAATTCAA
TAATAATCCAACAACAATTGCAGGAATTCATTTAAAAAATGACAATGTACCTGTAAGTGCGGCATTACAAGAAAATGTTG
AGAAAAACCCAGTTGATTTCAGTCAAATTCATATTTTAGATTATGATAATCAAACGAACTACTACAAAGCATTAGGTGTA
CCCGAGAAACAAATTCACGAAATCCCAGAAGATGAAAAAGTAGAAGCATTCATCAAGCATCATGCAAAAACAAAAGAAAA
TAAAGGTAAGCTAACGTTACAAGTCGTGACAATCGATACAGATGGAAGTATTGGTATTCCAATGAATGATGCGGTGTTAA
CGGCACGTGAAATCGTTCTTGTATTAACAGGTGCTGAAAAAGCTGAAGTTACACGTAAATTATACGAAGAAAATGGCAGC
ACAACATTTATCCCATCAAGTTTAAAATCTCATCGCATGGTCAATGTTGTTTTAGATGAGGCAGCAGCACAAGGCTTACC
AGAAGATGTTAGAACTTATTTCTCAGTACGTTTTGCATAA