100367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1144881..1145407 Replicon chromosome
Accession NZ_CP027846
Organism Staphylococcus kloosii strain ATCC 43959

Toxin (Protein)


Gene name mazF Uniprot ID A0A151A154
Locus tag C7J89_RS05600 Protein ID WP_061855667.1
Coordinates 1145048..1145407 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A151A0R3
Locus tag C7J89_RS05595 Protein ID WP_048793379.1
Coordinates 1144881..1145051 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7J89_RS05570 1140717..1141196 + 480 WP_103295723.1 PH domain-containing protein -
C7J89_RS05575 1141189..1142682 + 1494 WP_103295724.1 PH domain-containing protein -
C7J89_RS05580 1142675..1143157 + 483 WP_103295725.1 PH domain-containing protein -
C7J89_RS05585 1143186..1143539 + 354 WP_061855669.1 holo-ACP synthase -
C7J89_RS05590 1143646..1144794 + 1149 WP_061855668.1 alanine racemase -
C7J89_RS05595 1144881..1145051 + 171 WP_048793379.1 hypothetical protein Antitoxin
C7J89_RS05600 1145048..1145407 + 360 WP_061855667.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C7J89_RS05605 1145667..1146668 + 1002 WP_061855666.1 PP2C family protein-serine/threonine phosphatase -
C7J89_RS05610 1146749..1147075 + 327 WP_061855665.1 anti-sigma factor antagonist -
C7J89_RS05615 1147077..1147556 + 480 WP_061855664.1 anti-sigma B factor RsbW -
C7J89_RS05620 1147531..1148301 + 771 WP_061855663.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13479.70 Da        Isoelectric Point: 10.2885

>T100367 WP_061855667.1 NZ_CP027846:1145048-1145407 [Staphylococcus kloosii]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVNNALDISLGLHNVRNHK

Download         Length: 360 bp

>T100367 NZ_CP027846:1145048-1145407 [Staphylococcus kloosii]
TTGATGAGAAGAGGAGATGTATATCTAGCTGATTTATCACCAGTACAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATACAAAATGATACTGGTAATAAATATAGTCCTACCGTAATTGTGGCTGCAATTACTGGTAGGATTAATAAAGCTA
AAATTCCAACCCATGTAGAAATAGAAAAGAAAAAATATAAGTTGGATAAAGATTCGGTTATTCTGCTTGAACAAATAAGA
ACGTTAGATAAAAAGAGACTAAAAGAAAAATTAACGTATTTATCAGAAGACAAGATGAAAGAAGTCAATAATGCGCTTGA
TATTAGTTTAGGATTACATAATGTTAGAAATCACAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6242.68 Da        Isoelectric Point: 3.8099

>AT100367 WP_048793379.1 NZ_CP027846:1144881-1145051 [Staphylococcus kloosii]
MSSFNQSRNHNIEQSLKEGYSQMADLNLSLAAEAFPFECEACDCNESYLSSNNTSD

Download         Length: 171 bp

>AT100367 NZ_CP027846:1144881-1145051 [Staphylococcus kloosii]
ATGTCAAGCTTTAACCAAAGTAGAAACCATAATATAGAACAATCTTTAAAAGAAGGCTATTCTCAAATGGCTGATTTGAA
TCTCTCCCTTGCAGCAGAAGCTTTTCCCTTTGAATGTGAAGCTTGTGATTGCAATGAATCTTATCTTAGCTCAAATAATA
CAAGTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151A154

Antitoxin

Source ID Structure
AlphaFold DB A0A151A0R3

References