100366

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1133990..1134503 Replicon chromosome
Accession NZ_CP027846
Organism Staphylococcus kloosii strain ATCC 43959

Toxin (Protein)


Gene name TsdT Uniprot ID A0A151A0S0
Locus tag C7J89_RS05540 Protein ID WP_061855677.1
Coordinates 1134297..1134503 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A151A0Y7
Locus tag C7J89_RS05535 Protein ID WP_061855678.1
Coordinates 1133990..1134283 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7J89_RS05510 1129253..1130041 + 789 WP_103295728.1 hydroxyethylthiazole kinase -
C7J89_RS05515 1130045..1130683 + 639 WP_103295717.1 thiamine phosphate synthase -
C7J89_RS05520 1130771..1131640 + 870 WP_061855681.1 membrane protein insertase YidC -
C7J89_RS05525 1131704..1132345 - 642 WP_103295718.1 HD domain-containing protein -
C7J89_RS05530 1132366..1133850 - 1485 WP_103295719.1 cardiolipin synthase -
C7J89_RS05535 1133990..1134283 + 294 WP_061855678.1 copper-sensing transcriptional repressor CsoR Antitoxin
C7J89_RS05540 1134297..1134503 + 207 WP_061855677.1 hypothetical protein Toxin
C7J89_RS05545 1134640..1134780 + 141 WP_103295720.1 hypothetical protein -
C7J89_RS05550 1134826..1136043 - 1218 WP_103295721.1 rod shape-determining protein RodA -
C7J89_RS05555 1136307..1137377 + 1071 WP_061855675.1 D-alanine--D-alanine ligase -
C7J89_RS05560 1137390..1138745 + 1356 WP_103295722.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7586.64 Da        Isoelectric Point: 6.1995

>T100366 WP_061855677.1 NZ_CP027846:1134297-1134503 [Staphylococcus kloosii]
METKVIFVAGLNTAKQAEALTKDLLNIIGVHQVHVDSHNSSIQVTFTTPANLNNIEKEIYDRGYTIIF

Download         Length: 207 bp

>T100366 NZ_CP027846:1134297-1134503 [Staphylococcus kloosii]
ATGGAAACGAAAGTAATTTTTGTGGCAGGTCTAAATACTGCTAAGCAGGCAGAAGCACTAACAAAAGATTTATTAAATAT
AATTGGTGTTCATCAAGTTCATGTTGATAGTCACAATAGTTCTATTCAAGTCACTTTTACTACACCTGCCAATTTAAATA
ATATAGAAAAAGAAATTTATGATAGAGGGTATACAATAATCTTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11088.67 Da        Isoelectric Point: 6.4770

>AT100366 WP_061855678.1 NZ_CP027846:1133990-1134283 [Staphylococcus kloosii]
MVETSQAHHSTQTKNNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMEKIDNGEN
EAAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT100366 NZ_CP027846:1133990-1134283 [Staphylococcus kloosii]
ATGGTAGAAACATCTCAAGCCCATCATTCTACACAGACTAAAAACAACTTAAAATCACGTTTAAATCGTATTGAAGGCCA
AGTAAAAGCGATTAATCGTATGATTGATGAAGACGTATATTGTGATGATGTATTAACACAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACAAAACTGCTAGATCATCATATGAAGAGTTGTATTATGGAAAAAATAGACAACGGTGAAAAT
GAAGCGGCTATGGAAGAATTGCTAGTTACGTTTCAAAAATTAATGAAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151A0S0

Antitoxin

Source ID Structure
AlphaFold DB A0A151A0Y7

References