Detailed information of TA system TA100363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2193149..2193678
• Replicon: chromosome
• Accession: NZ_CP027806
• Organism: Candidatus Cyclonatronum proteinivorum strain Omega

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CYPRO_RS08485
• Protein ID: WP_114984208.1
• Coordinates: 2193149..2193352 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CYPRO_RS08490
• Protein ID: WP_114984209.1
• Coordinates: 2193358..2193678 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYPRO_RS08480	2189838..2192996	+	3159	WP_114984207.1	PD40 domain-containing protein	-
CYPRO_RS08485	2193149..2193352	+	204	WP_114984208.1	type II toxin-antitoxin system HicA family toxin	Toxin
CYPRO_RS08490	2193358..2193678	+	321	WP_114984209.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CYPRO_RS08495	2193776..2194003	-	228	WP_114984210.1	hypothetical protein	-
CYPRO_RS08500	2194156..2195547	-	1392	WP_114984211.1	NAD(P)(+) transhydrogenase (Re/Si-specific) subunit beta	-
CYPRO_RS08505	2195547..2195840	-	294	WP_114984212.1	NAD(P) transhydrogenase subunit alpha	-
CYPRO_RS08510	2195881..2197023	-	1143	WP_114984213.1	Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-62)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7406.58 Da
• Isoelectric Point: 11.8815

>T100363 WP_114984208.1 NZ_CP027806:2193149-2193352 [Candidatus Cyclonatronum proteinivorum]
IPAQRNLPAGYSESKKLSEGRGSRIRVALNGVRAVFHRPHPQKETDKGALKSVRRFLKEAGITPSKL

Nucleotide

• Length: 204 bp

>T100363 NZ_CP027806:2193149-2193352 [Candidatus Cyclonatronum proteinivorum]
ATTCCCGCGCAGCGAAATTTGCCCGCTGGCTATTCTGAATCTAAAAAACTCAGCGAAGGTCGCGGATCACGTATTCGGGT
TGCGCTGAACGGGGTTCGGGCTGTATTCCATCGCCCGCATCCGCAAAAAGAAACAGACAAAGGTGCGCTGAAGTCTGTTC
GGAGATTTTTGAAGGAAGCCGGAATTACACCCTCTAAATTATAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12345.91 Da
• Isoelectric Point: 6.0898

>AT100363 WP_114984209.1 NZ_CP027806:2193358-2193678 [Candidatus Cyclonatronum proteinivorum]
MLTYKGYHGKVLFDEDSGLLHGEVVYLRDVITFQGKSTDEIKQAFHDSVDDYLEFCSQRNEEPDKPFSGRLMLRLPSDTH
RKVYVRAKKEGKSLNEYITEKLSLEN

Nucleotide

• Length: 321 bp

>AT100363 NZ_CP027806:2193358-2193678 [Candidatus Cyclonatronum proteinivorum]
ATGTTAACCTATAAAGGATATCACGGGAAGGTCCTGTTCGATGAAGACAGCGGTCTTTTGCATGGTGAGGTCGTTTACCT
GCGCGATGTAATTACGTTTCAGGGCAAAAGCACTGATGAAATTAAGCAGGCTTTTCACGATTCTGTTGATGATTATCTCG
AGTTCTGCAGTCAGCGGAATGAAGAACCGGATAAGCCTTTTTCCGGACGACTGATGCTGCGACTTCCATCAGATACCCAT
CGGAAGGTGTATGTTCGGGCAAAAAAAGAAGGAAAAAGCCTGAATGAGTACATCACTGAAAAGCTATCCCTGGAAAATTG
A