Detailed information of TA system TA100362

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 936346..936893
• Replicon: chromosome
• Accession: NZ_CP027806
• Organism: Candidatus Cyclonatronum proteinivorum strain Omega

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CYPRO_RS03590
• Protein ID: WP_114983323.1
• Coordinates: 936346..936648 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CYPRO_RS03595
• Protein ID: WP_114983324.1
• Coordinates: 936636..936893 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYPRO_RS03580	932670..935114	-	2445	WP_114983322.1	DNA internalization-related competence protein ComEC/Rec2	-
CYPRO_RS03585	935265..935987	+	723	WP_114985680.1	PIG-L family deacetylase	-
CYPRO_RS03590	936346..936648	-	303	WP_114983323.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CYPRO_RS03595	936636..936893	-	258	WP_114983324.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CYPRO_RS03600	937578..939308	-	1731	WP_114983325.1	gamma-glutamyltransferase	-
CYPRO_RS03605	939789..940292	+	504	WP_124245508.1	winged helix-turn-helix transcriptional regulator	-
CYPRO_RS03610	940387..941130	+	744	WP_114983327.1	3-oxoacyl-[acyl-carrier-protein] reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11906.76 Da
• Isoelectric Point: 7.2770

>T100362 WP_114983323.1 NZ_CP027806:c936648-936346 [Candidatus Cyclonatronum proteinivorum]
MAQIIWTEPALQELDEIADYISLDNPNAARKLIRSVFKRVAQLREHPKSGKSVEDLEGSIYRRLLVSPCQIFYREENNRV
YIIHIIRDEQFLHLDILRMR

Nucleotide

• Length: 303 bp

>T100362 NZ_CP027806:c936648-936346 [Candidatus Cyclonatronum proteinivorum]
ATGGCTCAAATAATCTGGACGGAACCGGCACTTCAAGAACTCGATGAAATTGCTGACTACATCTCTCTGGACAATCCGAA
TGCTGCAAGGAAGCTTATTCGCAGCGTTTTTAAACGTGTCGCTCAATTACGCGAACATCCAAAATCAGGAAAATCGGTAG
AAGATCTGGAAGGGTCCATTTATCGCAGATTATTGGTTTCGCCTTGTCAGATTTTTTACAGAGAAGAAAATAACCGTGTC
TACATCATCCATATAATCAGAGATGAACAATTTCTTCATCTTGATATTCTCAGGATGCGGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9851.53 Da
• Isoelectric Point: 8.6083

>AT100362 WP_114983324.1 NZ_CP027806:c936893-936636 [Candidatus Cyclonatronum proteinivorum]
MKTELVTTLKLQATKILDELHREKEPVLITEHGKPSAYLVDVDSFESLLRRLKLLEGLARGEKAILEDRVVTHEEAQKKM
SRWLK

Nucleotide

• Length: 258 bp

>AT100362 NZ_CP027806:c936893-936636 [Candidatus Cyclonatronum proteinivorum]
ATGAAAACAGAACTTGTCACCACACTAAAACTTCAAGCCACAAAGATACTAGACGAACTCCACCGGGAGAAGGAGCCTGT
TTTGATCACAGAGCACGGCAAGCCATCCGCTTATCTTGTTGATGTGGATTCATTTGAAAGTTTACTTCGCAGGCTGAAGC
TCCTTGAAGGTCTTGCGCGAGGCGAAAAAGCTATCCTTGAAGATCGCGTGGTAACGCATGAAGAGGCCCAAAAGAAAATG
AGTCGATGGCTCAAATAA