Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4162407..4163026 Replicon chromosome
Accession NZ_CP027800
Organism Klebsiella pneumoniae subsp. pneumoniae strain VH1-2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag C7K65_RS20225 Protein ID WP_002892050.1
Coordinates 4162808..4163026 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag C7K65_RS20220 Protein ID WP_002892066.1
Coordinates 4162407..4162781 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7K65_RS20210 (4157559) 4157559..4158752 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C7K65_RS20215 (4158775) 4158775..4161921 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
C7K65_RS20220 (4162407) 4162407..4162781 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
C7K65_RS20225 (4162808) 4162808..4163026 + 219 WP_002892050.1 HHA domain-containing protein Toxin
C7K65_RS20230 (4163185) 4163185..4163751 + 567 WP_002892030.1 maltose O-acetyltransferase -
C7K65_RS20235 (4163723) 4163723..4163863 - 141 WP_004147370.1 hypothetical protein -
C7K65_RS20240 (4163884) 4163884..4164354 + 471 WP_002892026.1 YlaC family protein -
C7K65_RS20245 (4164329) 4164329..4165780 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
C7K65_RS20250 (4165881) 4165881..4166579 + 699 WP_002892021.1 GNAT family protein -
C7K65_RS20255 (4166576) 4166576..4166716 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
C7K65_RS20260 (4166716) 4166716..4166979 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T100343 WP_002892050.1 NZ_CP027800:4162808-4163026 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T100343 NZ_CP027800:4162808-4163026 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT100343 WP_002892066.1 NZ_CP027800:4162407-4162781 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT100343 NZ_CP027800:4162407-4162781 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References