Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 20674..21266 Replicon plasmid pTAB7A
Accession NZ_CP027790
Organism Bacillus licheniformis strain TAB7

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C7M53_RS22990 Protein ID WP_119953980.1
Coordinates 20943..21266 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C7M53_RS22985 Protein ID WP_048406251.1
Coordinates 20674..20943 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M53_RS22955 15804..16112 + 309 WP_017474131.1 hypothetical protein -
C7M53_RS22960 16109..16363 + 255 WP_017474130.1 hypothetical protein -
C7M53_RS22965 16793..17122 - 330 WP_119953974.1 YolD-like family protein -
C7M53_RS22970 17650..17856 + 207 WP_048406504.1 hypothetical protein -
C7M53_RS23655 18230..18400 + 171 WP_164504587.1 hypothetical protein -
C7M53_RS22975 19027..19959 + 933 WP_119953976.1 tyrosine-type recombinase/integrase -
C7M53_RS22980 20170..20355 + 186 WP_119953978.1 hypothetical protein -
C7M53_RS22985 20674..20943 + 270 WP_048406251.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C7M53_RS22990 20943..21266 + 324 WP_119953980.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C7M53_RS22995 21705..22805 + 1101 WP_119953982.1 tetratricopeptide repeat protein -
C7M53_RS23000 23003..23185 - 183 WP_119953984.1 hypothetical protein -
C7M53_RS23010 23856..24881 - 1026 WP_017474177.1 DUF2325 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..42138 42138


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-96)

Antitoxin

SpoVT-AbrB domain

(17-61)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12002.70 Da        Isoelectric Point: 5.6376

>T100328 WP_119953980.1 NZ_CP027790:20943-21266 [Bacillus licheniformis]
MSVERGDLVYLNFNPQAGHEQAGRRPAIVLSPKNFNQTTGFAVVCPITNQQKSYPFEVALPDGLAIQGVILTDQVKSLDW
RARRFQVVDQAPEIIVSECLDYIHTFL

Download         Length: 324 bp

>T100328 NZ_CP027790:20943-21266 [Bacillus licheniformis]
ATGTCAGTTGAACGTGGTGATCTTGTTTATTTAAACTTTAATCCACAGGCAGGACATGAACAAGCTGGAAGAAGGCCAGC
TATTGTCTTATCTCCGAAAAATTTTAATCAAACCACTGGGTTTGCAGTGGTCTGTCCGATCACTAACCAACAGAAAAGTT
ATCCCTTTGAGGTAGCTTTGCCTGATGGCTTGGCTATCCAAGGGGTTATATTAACAGATCAGGTGAAAAGTTTGGATTGG
AGAGCCCGCCGGTTCCAAGTTGTAGATCAAGCTCCCGAAATAATTGTTAGTGAATGCTTGGACTATATACATACTTTTCT
ATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9939.27 Da        Isoelectric Point: 5.1667

>AT100328 WP_048406251.1 NZ_CP027790:20674-20943 [Bacillus licheniformis]
MEENKREGVVSVTTTVQKWGNSLAVRIPTRIAESISMEQGTEIELTVGKTGIMLKPKNNKPTLDDLLARVTPENRHSEVD
FGREGNELF

Download         Length: 270 bp

>AT100328 NZ_CP027790:20674-20943 [Bacillus licheniformis]
ATGGAGGAAAATAAACGAGAAGGAGTGGTGAGTGTGACAACAACGGTTCAAAAATGGGGGAACAGCCTTGCCGTTCGCAT
CCCTACTCGTATTGCTGAATCTATCTCCATGGAACAAGGCACAGAGATCGAATTAACTGTCGGAAAGACTGGGATTATGT
TAAAACCTAAAAATAATAAACCAACATTAGATGACCTTTTAGCACGCGTAACACCCGAAAATCGGCATTCTGAAGTGGAT
TTTGGCCGTGAAGGGAATGAATTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References