100315

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 2221056..2221681 Replicon chromosome
Accession NZ_CP027788
Organism Staphylococcus aureus strain CMRSA-6

Toxin (Protein)


Gene name doc Uniprot ID A0A380FZ43
Locus tag C7M55_RS11800 Protein ID WP_001179607.1
Coordinates 2221056..2221451 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A380FXS4
Locus tag C7M55_RS11805 Protein ID WP_000258939.1
Coordinates 2221451..2221681 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M55_RS11760 2216611..2217051 - 441 Protein_2176 GNAT family N-acetyltransferase -
C7M55_RS11765 2217026..2217277 - 252 WP_002505594.1 hypothetical protein -
C7M55_RS11770 2217274..2217909 - 636 Protein_2178 aminoglycoside 6-adenylyltransferase -
C7M55_RS11775 2218124..2218846 - 723 WP_001043218.1 hypothetical protein -
C7M55_RS11780 2218955..2219755 - 801 WP_000686449.1 metallophosphoesterase -
C7M55_RS11785 2219759..2220253 - 495 WP_000280790.1 hypothetical protein -
C7M55_RS11790 2220310..2220579 - 270 WP_000755772.1 hypothetical protein -
C7M55_RS11795 2220563..2220754 - 192 WP_032605691.1 hypothetical protein -
C7M55_RS11800 2221056..2221451 - 396 WP_001179607.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
C7M55_RS11805 2221451..2221681 - 231 WP_000258939.1 addiction module antitoxin Antitoxin
C7M55_RS11810 2221857..2222378 - 522 WP_000639078.1 metallophosphoesterase -
C7M55_RS11815 2222378..2223028 - 651 WP_000411528.1 hypothetical protein -
C7M55_RS11820 2223028..2223345 - 318 WP_001807410.1 hypothetical protein -
C7M55_RS11825 2223338..2224063 - 726 WP_000197304.1 metallophosphoesterase -
C7M55_RS11830 2224063..2224284 - 222 WP_000829423.1 hypothetical protein -
C7M55_RS16190 2224304..2224480 - 177 WP_000063384.1 hypothetical protein -
C7M55_RS11835 2224473..2225015 - 543 WP_000858632.1 hypothetical protein -
C7M55_RS11840 2225030..2225302 - 273 WP_000691100.1 hypothetical protein -
C7M55_RS11845 2225328..2225483 - 156 WP_000792995.1 transcriptional regulator -
C7M55_RS16195 2225597..2225764 - 168 WP_000312832.1 hypothetical protein -
C7M55_RS11850 2225780..2225965 - 186 WP_001187008.1 hypothetical protein -
C7M55_RS11855 2225950..2226129 - 180 WP_000401832.1 hypothetical protein -
C7M55_RS11860 2226143..2226625 - 483 WP_000833764.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-aph(2'') / aph(3')-III - 2183269..2310694 127425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15035.51 Da        Isoelectric Point: 9.4574

>T100315 WP_001179607.1 NZ_CP027788:c2221451-2221056 [Staphylococcus aureus]
MQNIKYLTEKQVIAINVKAIQELSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFFNANKR
TAFTSMVIFLKLNKINFNCTQDEAVQFTLKVVEDKTLTLEDIADWIKRHCK

Download         Length: 396 bp

>T100315 NZ_CP027788:c2221451-2221056 [Staphylococcus aureus]
ATGCAAAACATTAAATATTTAACTGAAAAACAAGTAATTGCCATTAATGTAAAAGCAATTCAAGAACTCTCACCTAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAGGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTTGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCGGCTTTTATATACAGAAATATAGCTCAAAAACATGCATTCTTTAATGCGAATAAGAGA
ACAGCTTTTACATCTATGGTTATTTTCTTGAAGTTAAATAAGATTAATTTTAATTGTACTCAAGACGAAGCGGTACAATT
TACTTTAAAAGTGGTAGAGGATAAAACTCTTACACTTGAAGATATTGCAGATTGGATCAAAAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8617.73 Da        Isoelectric Point: 4.4501

>AT100315 WP_000258939.1 NZ_CP027788:c2221681-2221451 [Staphylococcus aureus]
MVTTRKLRRAGNSSVVSVPTEVIAALGVTNGDNLKFNIEDNKVTIEKEVNEDEEFFKLLDETFTEYNQALRKLVDI

Download         Length: 231 bp

>AT100315 NZ_CP027788:c2221681-2221451 [Staphylococcus aureus]
ATGGTTACTACAAGAAAACTAAGAAGAGCTGGCAATAGTTCAGTTGTTTCTGTACCAACAGAAGTGATCGCAGCACTCGG
AGTTACAAATGGTGACAATCTTAAATTTAATATTGAAGATAATAAAGTAACCATTGAAAAGGAGGTAAACGAAGACGAAG
AGTTTTTCAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTCTGAGAAAGTTGGTTGACATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380FZ43

Antitoxin

Source ID Structure
AlphaFold DB A0A380FXS4

References