Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/-
Location 3409..4316 Replicon chromosome
Accession NZ_JSDP01000312
Organism Aphanizomenon flos-aquae 2012/KM1/D3 spades_34_len_T:34268

Toxin (Protein)


Gene name hepT Uniprot ID -
Locus tag OA07_RS26470 Protein ID WP_052150109.1
Coordinates 3873..4316 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag OA07_RS26465 Protein ID WP_235335441.1
Coordinates 3409..3876 (+) Length 156 a.a.

Genomic Context

OA07_RS26430OA07_RS26435OA07_RS26440OA07_RS26455OA07_RS26460OA07_RS26465OA07_RS26470OA07_RS26475OA07_RS26480OA07_RS26485OA07_RS26445OA07_RS26450
Location: 1..294 (294 bp)
Type: Others
Protein ID: Protein_0
Location: 458..652 (195 bp)
Type: Others
Protein ID: WP_039205087.1
Location: 652..1266 (615 bp)
Type: Others
Protein ID: WP_039205089.1
Location: 2782..3009 (228 bp)
Type: Others
Protein ID: WP_039205093.1
Location: 3157..3393 (237 bp)
Type: Others
Protein ID: WP_039205095.1
Location: 3409..3876 (468 bp)
Type: Antitoxin
Protein ID: WP_235335441.1
Location: 3873..4316 (444 bp)
Type: Toxin
Protein ID: WP_052150109.1
Location: 4309..7005 (2697 bp)
Type: Others
Protein ID: WP_039205098.1
Location: 7034..8059 (1026 bp)
Type: Others
Protein ID: WP_039205100.1
Location: 8063..8821 (759 bp)
Type: Others
Protein ID: WP_039205101.1
Location: 1249..1575 (327 bp)
Type: Others
Protein ID: WP_052150108.1
Location: 1805..2671 (867 bp)
Type: Others
Protein ID: WP_039205091.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OA07_RS26430 (OA07_26415)1..294+294Protein_0potassium-transporting ATPase subunit B-
OA07_RS26435 (OA07_26420)458..652+195WP_039205087.1potassium-transporting ATPase subunit F-
OA07_RS26440 (OA07_26425)652..1266+615WP_039205089.1K(+)-transporting ATPase subunit C-
OA07_RS26445 (OA07_26430)1249..1575-327WP_052150108.1hypothetical protein-
OA07_RS26450 (OA07_26435)1805..2671-867WP_039205091.1WYL domain-containing protein-
OA07_RS26455 (OA07_26440)2782..3009+228WP_039205093.1hypothetical protein-
OA07_RS26460 (OA07_26445)3157..3393+237WP_039205095.1DUF433 domain-containing protein-
OA07_RS26465 (OA07_26450)3409..3876+468WP_235335441.1type VII toxin-antitoxin system antitoxin protein adenylyltransferase MntAAntitoxin
OA07_RS26470 (OA07_26455)3873..4316+444WP_052150109.1type VII toxin-antitoxin system toxin tRNA nuclease HepTToxin
OA07_RS26475 (OA07_26460)4309..7005+2697WP_039205098.1CRISPR-associated protein Csc3-
OA07_RS26480 (OA07_26465)7034..8059+1026WP_039205100.1type I-D CRISPR-associated protein Cas7/Csc2-
OA07_RS26485 (OA07_26470)8063..8821+759WP_039205101.1type I-D CRISPR-associated protein Cas5/Csc1-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(18-133)

Antitoxin

Polymerase beta, nucleotidyltransferase

(24-116)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 17109.52 Da        Isoelectric Point: 4.4587

>T10031 WP_052150109.1 NZ_JSDP01000312:3873-4316 [Aphanizomenon flos-aquae 2012/KM1/D3]
MTNIEPVIIETRLELIGRYLDHLKKFENISLDDYLSSFEQQLITERLLQLITQAAIDINDHILSKLKSGKSYTNFEAFIE
LGKYQILTPELAKQIAPSSGLRNRLVHEYDDIDPNQVFMAISFALQQYPLYVRQINSYLITLEEEND

Download         Length: 444 bp

>T10031 NZ_JSDP01000312:3873-4316 [Aphanizomenon flos-aquae 2012/KM1/D3]
ATGACAAATATAGAACCTGTGATTATTGAAACTAGACTGGAGTTGATAGGTCGTTATCTTGATCACCTCAAAAAATTTGA
AAATATTAGTTTAGATGATTATTTGAGTAGTTTTGAACAGCAATTAATTACAGAAAGACTATTGCAATTAATAACTCAAG
CTGCAATAGACATCAATGATCATATATTGTCAAAACTCAAATCTGGAAAGTCTTACACTAATTTTGAGGCTTTCATTGAA
TTGGGTAAATATCAAATTCTTACTCCCGAACTAGCAAAACAGATTGCACCATCATCAGGTTTAAGAAATCGTTTGGTTCA
TGAATATGATGATATAGATCCGAATCAGGTTTTCATGGCAATTAGTTTTGCGTTACAGCAATATCCGCTTTATGTTAGAC
AAATCAACTCTTATTTAATTACATTGGAAGAAGAAAATGATTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17930.66 Da        Isoelectric Point: 5.0501

>AT10031 WP_235335441.1 NZ_JSDP01000312:3409-3876 [Aphanizomenon flos-aquae 2012/KM1/D3]
VDNDKMQDKIPTIAELRELSLRLLTKIPYLKMLVLFGSRATGNINANSDWDFAVLYDEEKYNLYIQNNPLAAFVIPGILG
EIFKINSDKIDIVELNHCSKLIAHFVARDGKVLYEEPGDEFDKFQQRVLLSNTEIKKIEKTKLENIENFLQRWGV

Download         Length: 468 bp

>AT10031 NZ_JSDP01000312:3409-3876 [Aphanizomenon flos-aquae 2012/KM1/D3]
GTGGATAATGATAAAATGCAAGATAAAATTCCAACAATTGCAGAACTTCGAGAACTTTCTTTACGACTTCTTACAAAAAT
ACCTTACTTAAAAATGTTAGTTCTGTTTGGTTCTAGAGCAACAGGTAACATTAACGCCAATAGTGACTGGGATTTTGCTG
TTTTATATGATGAAGAAAAATATAATTTATACATTCAAAATAATCCATTAGCTGCATTTGTAATACCTGGAATTTTAGGA
GAAATATTCAAAATCAATTCTGACAAAATTGATATTGTAGAACTTAATCATTGTTCAAAACTCATAGCACATTTTGTAGC
TCGTGATGGAAAGGTATTATATGAAGAACCAGGAGATGAGTTTGATAAATTTCAACAAAGAGTTTTATTGAGTAATACAG
AAATTAAAAAGATTGAAAAAACTAAATTAGAAAACATTGAGAATTTTTTACAAAGGTGGGGAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Yingjie Song et al. (2023) Comparative analysis of five type II TA systems identified in Pseudomonas aeruginosa reveals their contributions to persistence and intracellular survival. Frontiers in Cellular And Infection Microbiology 13:1127786. [PubMed:36844395] experimental

(2) Inga Songailiene et al. (2020) HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Molecular Cell 80(6):955-970.e7. [PubMed:33290744] experimental


experimental experimental literature