Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 941364..941841 Replicon chromosome
Accession NZ_CP027788
Organism Staphylococcus aureus strain CMRSA-6

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag C7M55_RS04865 Protein ID WP_000052078.1
Coordinates 941364..941552 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C7M55_RS04870 Protein ID WP_001059690.1
Coordinates 941581..941841 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M55_RS04835 937404..937874 + 471 WP_000824472.1 hypothetical protein -
C7M55_RS04840 938215..938901 + 687 WP_001548082.1 thermonuclease family protein -
C7M55_RS04845 939258..939458 + 201 WP_001059082.1 cold-shock protein -
C7M55_RS04850 939955..940173 - 219 WP_000005886.1 hypothetical protein -
C7M55_RS04855 940235..940519 - 285 WP_001004395.1 hypothetical protein -
C7M55_RS04860 940607..941176 - 570 WP_001106654.1 hypothetical protein -
C7M55_RS04865 941364..941552 - 189 WP_000052078.1 hypothetical protein Toxin
C7M55_RS04870 941581..941841 - 261 WP_001059690.1 hypothetical protein Antitoxin
C7M55_RS04875 942182..942385 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C7M55_RS04880 942382..942618 - 237 WP_000368687.1 hypothetical protein -
C7M55_RS04885 942843..943424 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
C7M55_RS04890 943497..944114 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
C7M55_RS04895 944269..944763 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
C7M55_RS04900 945162..945584 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
C7M55_RS04905 945732..946448 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 936047..966109 30062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T100306 WP_000052078.1 NZ_CP027788:c941552-941364 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T100306 NZ_CP027788:c941552-941364 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT100306 WP_001059690.1 NZ_CP027788:c941841-941581 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT100306 NZ_CP027788:c941841-941581 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References