Detailed information of TA system TA100300

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 415492..415985
• Replicon: chromosome
• Accession: NZ_CP027783
• Organism: Tetragenococcus osmophilus strain JCM 31126

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C7K38_RS02045
• Protein ID: WP_123934333.1
• Coordinates: 415492..415758 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C7K38_RS02050
• Protein ID: WP_123934335.1
• Coordinates: 415755..415985 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7K38_RS02025	410578..412434	-	1857	WP_123934325.1	beta-glucoside-specific PTS transporter subunit IIABC	-
C7K38_RS02030	412764..413462	+	699	WP_123934327.1	DUF969 domain-containing protein	-
C7K38_RS02035	413455..414375	+	921	WP_123934329.1	DUF979 domain-containing protein	-
C7K38_RS02040	414422..415069	+	648	WP_123934331.1	pyroglutamyl-peptidase I	-
C7K38_RS02045	415492..415758	-	267	WP_123934333.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C7K38_RS02050	415755..415985	-	231	WP_123934335.1	antitoxin	Antitoxin
C7K38_RS02055	416231..417337	+	1107	WP_123934337.1	Ldh family oxidoreductase	-
C7K38_RS02060	417519..418763	+	1245	WP_123934339.1	divalent metal cation transporter	-
C7K38_RS02065	418947..420116	-	1170	WP_123934340.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
C7K38_RS02070	420135..420839	-	705	WP_123934342.1	SIS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10486.11 Da
• Isoelectric Point: 10.3514

>T100300 WP_123934333.1 NZ_CP027783:c415758-415492 [Tetragenococcus osmophilus]
MSYRLVFTSEVQKQFRKMDKYQATLITRWLYQNIDGIDDPRKFGKDLTANRSGQWRYKIGKYRVIVEIEGSQLVVLVVQV
GHRKNVYD

Nucleotide

• Length: 267 bp

>T100300 NZ_CP027783:c415758-415492 [Tetragenococcus osmophilus]
ATGAGCTATCGCTTAGTCTTTACGTCTGAAGTGCAAAAACAATTTCGAAAGATGGATAAATACCAAGCTACCTTAATTAC
TCGTTGGTTATATCAAAATATTGATGGAATTGACGATCCTCGCAAATTTGGCAAAGATCTAACTGCTAATCGGTCTGGAC
AATGGCGGTATAAAATTGGCAAATATCGCGTTATAGTTGAAATAGAAGGCAGCCAATTGGTTGTGCTTGTTGTTCAAGTT
GGGCATAGGAAAAATGTTTATGATTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8844.94 Da
• Isoelectric Point: 3.8308

>AT100300 WP_123934335.1 NZ_CP027783:c415985-415755 [Tetragenococcus osmophilus]
MAMITVRVSDAEKEWLDYMANFYGISLSDLLKTYSMEQLEDEYDCQTADIAYKRWLENGKQTVSMDEILTEFGGLE

Nucleotide

• Length: 231 bp

>AT100300 NZ_CP027783:c415985-415755 [Tetragenococcus osmophilus]
ATGGCTATGATCACAGTACGTGTGAGCGACGCGGAAAAAGAATGGTTGGATTATATGGCTAATTTCTATGGAATTTCTTT
GTCCGATCTATTAAAAACATATTCGATGGAACAATTAGAAGATGAGTATGACTGTCAAACGGCTGATATCGCATATAAAC
GTTGGTTAGAAAATGGGAAACAAACGGTATCCATGGATGAAATCCTCACTGAATTTGGAGGTTTAGAATGA