Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 194201..194802 Replicon chromosome
Accession NZ_CP027783
Organism Tetragenococcus osmophilus strain JCM 31126

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag C7K38_RS01025 Protein ID WP_123933974.1
Coordinates 194201..194545 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag C7K38_RS01030 Protein ID WP_123933976.1
Coordinates 194539..194802 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7K38_RS01005 190299..190997 - 699 WP_123933968.1 response regulator transcription factor -
C7K38_RS01010 191221..191965 + 745 Protein_197 cyclase family protein -
C7K38_RS01015 192129..193208 - 1080 WP_123933970.1 LD-carboxypeptidase -
C7K38_RS01020 193365..193958 + 594 WP_123933972.1 DJ-1/PfpI family protein -
C7K38_RS01025 194201..194545 - 345 WP_123933974.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C7K38_RS01030 194539..194802 - 264 WP_123933976.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C7K38_RS01035 194888..195595 - 708 WP_123933978.1 hydroxyacylglutathione hydrolase -
C7K38_RS01040 195761..196531 + 771 WP_028790115.1 DeoR/GlpR family DNA-binding transcription regulator -
C7K38_RS01045 196524..196757 + 234 WP_123933980.1 HAD hydrolase-like protein -
C7K38_RS01050 196904..198226 + 1323 WP_123933982.1 IS1380 family transposase -
C7K38_RS01055 198486..199409 + 924 WP_123933984.1 sugar-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-101)

Antitoxin

SpoVT-AbrB domain

(12-53)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13007.87 Da        Isoelectric Point: 5.7167

>T100299 WP_123933974.1 NZ_CP027783:c194545-194201 [Tetragenococcus osmophilus]
VVTQGDIFYVDFNPRRGHEQRSRRPAIALSHDMVQQTSNMTIVAPISSTKRDFPMYYSLESTKVIYGKVLLDQTIALDLQ
ARNVTEADIVDKVSKKELTEIIAIYKLLFSVDDE

Download         Length: 345 bp

>T100299 NZ_CP027783:c194545-194201 [Tetragenococcus osmophilus]
GTGGTAACCCAGGGAGATATTTTTTATGTGGACTTTAATCCAAGACGAGGTCATGAACAGAGGAGTCGACGTCCAGCAAT
TGCTTTAAGCCACGATATGGTGCAGCAAACAAGTAATATGACAATTGTAGCCCCCATTAGCTCAACAAAACGTGATTTTC
CCATGTATTATTCTTTGGAAAGTACCAAAGTTATTTATGGAAAAGTCTTATTGGACCAAACAATTGCATTAGATCTACAG
GCAAGAAATGTAACGGAAGCAGACATTGTGGATAAGGTTTCTAAAAAAGAATTAACTGAGATCATTGCTATTTATAAGTT
ATTATTTAGCGTTGATGATGAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10041.20 Da        Isoelectric Point: 5.0197

>AT100299 WP_123933976.1 NZ_CP027783:c194802-194539 [Tetragenococcus osmophilus]
MNNIKDQTRITQWGNSKATRIPSYIVKQLGLEDNQVLSVTIQNNSIILTPIKKQPTNIHDLFAGWQDDGQRDHELDWGKE
EGNELPW

Download         Length: 264 bp

>AT100299 NZ_CP027783:c194802-194539 [Tetragenococcus osmophilus]
ATGAATAACATTAAAGATCAAACTCGTATTACACAGTGGGGAAATTCGAAAGCTACTCGAATCCCAAGTTATATTGTAAA
ACAATTAGGTTTAGAAGATAATCAAGTCTTATCTGTAACTATCCAAAATAACTCAATCATTTTAACACCTATAAAAAAAC
AGCCGACTAATATTCATGACCTTTTTGCAGGCTGGCAAGATGACGGACAACGTGATCATGAGTTAGATTGGGGGAAAGAA
GAAGGTAACGAATTACCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References