Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapB-relB/VapC-Phd
Location 1061364..1062042 Replicon chromosome
Accession NZ_CP027773
Organism Variovorax sp. PMC12

Toxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C4F17_RS04880 Protein ID WP_081269505.1
Coordinates 1061629..1062042 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C4F17_RS04875 Protein ID WP_106934468.1
Coordinates 1061364..1061621 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4F17_RS04860 1057055..1057849 + 795 WP_081269501.1 response regulator transcription factor -
C4F17_RS04865 1057858..1058844 + 987 WP_106934467.1 ATP-binding protein -
C4F17_RS04870 1058925..1061300 + 2376 WP_081269503.1 RNA-binding transcriptional accessory protein -
C4F17_RS04875 1061364..1061621 + 258 WP_106934468.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C4F17_RS04880 1061629..1062042 + 414 WP_081269505.1 type II toxin-antitoxin system VapC family toxin Toxin
C4F17_RS04885 1062039..1063124 + 1086 WP_106934469.1 patatin-like phospholipase family protein -
C4F17_RS04890 1063088..1063483 - 396 WP_106934470.1 hypothetical protein -
C4F17_RS04895 1063480..1063863 - 384 WP_106934471.1 RidA family protein -
C4F17_RS04900 1063860..1065377 - 1518 WP_106934472.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-63)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15258.31 Da        Isoelectric Point: 4.7286

>T100298 WP_081269505.1 NZ_CP027773:1061629-1062042 [Variovorax sp. PMC12]
MYLLDTNVISELRRPRPHGAVLEWLTPVADSDLHLSAVTLGEIQAGIELTREQDAAKASEIEQWASLVAASYNVLPMDAE
TFRLWAKLMHRSSNTLYEDAMIAATAKQHALTVVTRNVNDFAGFGVEILNPFEYTRA

Download         Length: 414 bp

>T100298 NZ_CP027773:1061629-1062042 [Variovorax sp. PMC12]
ATGTACCTGCTGGACACGAACGTGATTTCCGAGCTTCGCAGGCCTCGTCCGCATGGGGCGGTCCTCGAGTGGCTCACGCC
TGTTGCAGACAGCGACCTTCATCTGTCGGCGGTGACGCTCGGAGAGATCCAGGCCGGCATCGAACTCACGCGCGAACAGG
ACGCTGCGAAGGCCAGCGAGATCGAACAATGGGCCTCGCTGGTCGCTGCGTCGTACAACGTGCTTCCCATGGACGCGGAA
ACCTTCAGGCTCTGGGCGAAACTGATGCATCGCAGCTCGAACACGCTGTATGAGGACGCGATGATTGCCGCCACGGCAAA
GCAGCACGCGCTCACCGTGGTAACCCGCAACGTGAATGACTTCGCGGGGTTCGGTGTCGAAATACTCAATCCCTTCGAAT
ACACGCGGGCATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9488.07 Da        Isoelectric Point: 11.4778

>AT100298 WP_106934468.1 NZ_CP027773:1061364-1061621 [Variovorax sp. PMC12]
MKTWAVQDAKARFSEFLEASLVEGPQMVTKRGAEVAVLVPAAEWRRLHATAKPSLKELLLSADARTEFLVPQRGAARRRS
VTPMR

Download         Length: 258 bp

>AT100298 NZ_CP027773:1061364-1061621 [Variovorax sp. PMC12]
ATGAAAACCTGGGCTGTGCAGGATGCCAAGGCGCGATTCAGCGAGTTCCTCGAGGCTTCCCTGGTCGAGGGGCCGCAAAT
GGTGACGAAGCGCGGCGCCGAGGTGGCTGTGCTCGTTCCGGCAGCGGAATGGCGGCGTTTGCATGCGACTGCCAAGCCGT
CGCTCAAGGAGCTGCTTCTTTCGGCGGACGCACGCACCGAGTTCCTGGTCCCGCAGCGGGGCGCCGCGCGCAGGCGCAGC
GTCACGCCCATGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References