Detailed information of TA system TA100297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1616557..1617169
• Replicon: chromosome
• Accession: NZ_CP027771
• Organism: Streptococcus pyogenes strain DMG1800716

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: C7K40_RS08195
• Protein ID: WP_002982731.1
• Coordinates: 1616834..1617169 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: C7K40_RS08190
• Protein ID: WP_002988079.1
• Coordinates: 1616557..1616844 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7K40_RS08165	1611736..1612719	-	984	WP_023610648.1	tagatose-bisphosphate aldolase	-
C7K40_RS08170	1612723..1613652	-	930	WP_023612888.1	tagatose-6-phosphate kinase	-
C7K40_RS08175	1613698..1614213	-	516	WP_023612880.1	galactose-6-phosphate isomerase subunit LacB	-
C7K40_RS08180	1614248..1614676	-	429	WP_023612877.1	galactose-6-phosphate isomerase subunit LacA	-
C7K40_RS08185	1615121..1615894	+	774	WP_023612896.1	DeoR/GlpR family DNA-binding transcription regulator	-
C7K40_RS08190	1616557..1616844	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
C7K40_RS08195	1616834..1617169	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C7K40_RS08200	1617258..1618301	+	1044	Protein_1512	site-specific integrase	-
C7K40_RS08205	1618434..1618826	-	393	WP_002982716.1	30S ribosomal protein S9	-
C7K40_RS08210	1618847..1619293	-	447	WP_002982710.1	50S ribosomal protein L13	-
C7K40_RS08215	1619511..1619717	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
C7K40_RS08220	1619714..1620412	-	699	WP_011018229.1	hypothetical protein	-
C7K40_RS08225	1620548..1621408	-	861	WP_023612881.1	DegV family protein	-
C7K40_RS08230	1621505..1622023	-	519	WP_023612882.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T100297 WP_002982731.1 NZ_CP027771:1616834-1617169 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T100297 NZ_CP027771:1616834-1617169 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT100297 WP_002988079.1 NZ_CP027771:1616557-1616844 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT100297 NZ_CP027771:1616557-1616844 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCTGTTACCTTTCAAGCTAATAAAGAATTGGTAAGTGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A4U7GX94