Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 19877..20401 Replicon chromosome
Accession NZ_CP027770
Organism Staphylococcus felis strain ATCC 49168

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag C7J90_RS00110 Protein ID WP_103207283.1
Coordinates 19877..20101 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag C7J90_RS00115 Protein ID WP_103207284.1
Coordinates 20114..20401 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7J90_RS00095 15794..16990 + 1197 WP_103207280.1 rod shape-determining protein RodA -
C7J90_RS11955 17124..17264 - 141 WP_167388982.1 hypothetical protein -
C7J90_RS00100 17353..19539 - 2187 WP_103207380.1 heavy metal translocating P-type ATPase -
C7J90_RS00105 19669..19875 - 207 WP_103207281.1 cation transporter -
C7J90_RS00110 19877..20101 - 225 WP_103207283.1 cation transporter Toxin
C7J90_RS00115 20114..20401 - 288 WP_103207284.1 copper-sensing transcriptional repressor CsoR Antitoxin
C7J90_RS00120 20535..22025 + 1491 WP_103207286.1 cardiolipin synthase -
C7J90_RS00125 22041..22688 + 648 WP_103207287.1 HD domain-containing protein -
C7J90_RS00130 22856..23716 - 861 WP_103207289.1 membrane protein insertase YidC -
C7J90_RS00135 23804..24442 - 639 WP_103207290.1 thiamine phosphate synthase -
C7J90_RS00140 24445..25236 - 792 WP_103207292.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(6-64)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8430.43 Da        Isoelectric Point: 4.1429

>T100295 WP_103207283.1 NZ_CP027770:c20101-19877 [Staphylococcus felis]
MYQSYVQVSNIHTENDKEALEKRLSSMIGVLDVQIDINQQCVNLEYETPANLNTLEKEIYDAGFPVINSFKGGY

Download         Length: 225 bp

>T100295 NZ_CP027770:c20101-19877 [Staphylococcus felis]
ATGTATCAAAGTTATGTGCAAGTCTCGAACATTCATACAGAAAATGATAAAGAAGCTTTAGAAAAACGTTTATCTTCTAT
GATTGGGGTATTGGATGTTCAAATTGATATCAATCAGCAATGTGTCAACCTAGAATATGAAACACCAGCAAATCTTAACA
CGTTAGAAAAAGAAATCTATGATGCAGGTTTTCCTGTTATCAATTCATTCAAAGGAGGATATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11005.63 Da        Isoelectric Point: 6.8618

>AT100295 WP_103207284.1 NZ_CP027770:c20401-20114 [Staphylococcus felis]
MTEQAHHSDSIKRNLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDYHMKGCIMHKIENGSEQE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT100295 NZ_CP027770:c20401-20114 [Staphylococcus felis]
ATGACTGAACAAGCACATCATTCTGATTCGATAAAGCGTAATTTAAAGTCGCGTTTGAATCGCATTGAAGGACAAGTACG
TGCCATCAATCGTATGATAGATGAAGATGTCTATTGTGATGATGTTTTAACGCAAATTAGAGCAACACGATCTGCTTTAA
ATAGCGTAGCGACAAAATTATTAGATTATCACATGAAAGGTTGTATTATGCATAAAATTGAAAATGGTTCTGAACAAGAA
GCTATGGAAGAATTACTTGTGACGTTCCAGAAATTAATGAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References