Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 6397..6927 Replicon chromosome
Accession NZ_CP027770
Organism Staphylococcus felis strain ATCC 49168

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C7J90_RS00045 Protein ID WP_103207265.1
Coordinates 6397..6756 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C7J90_RS00050 Protein ID WP_103207266.1
Coordinates 6757..6927 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7J90_RS00025 3515..4285 - 771 WP_103207260.1 RNA polymerase sigma factor SigB -
C7J90_RS00030 4260..4739 - 480 WP_103207378.1 anti-sigma B factor RsbW -
C7J90_RS00035 4742..5068 - 327 WP_103207262.1 anti-sigma factor antagonist -
C7J90_RS00040 5146..6150 - 1005 WP_103207263.1 PP2C family protein-serine/threonine phosphatase -
C7J90_RS00045 6397..6756 - 360 WP_103207265.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C7J90_RS00050 6757..6927 - 171 WP_103207266.1 antitoxin MazE Antitoxin
C7J90_RS00055 7009..8157 - 1149 WP_103207268.1 alanine racemase -
C7J90_RS00060 8285..8641 - 357 WP_103207269.1 holo-ACP synthase -
C7J90_RS00065 8638..9183 - 546 WP_103207271.1 PH domain-containing protein -
C7J90_RS00070 9164..10681 - 1518 WP_103207272.1 PH domain-containing protein -
C7J90_RS00075 10674..11147 - 474 WP_103207274.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13331.49 Da        Isoelectric Point: 10.1421

>T100294 WP_103207265.1 NZ_CP027770:c6756-6397 [Staphylococcus felis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKQKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDEKMKEVNNALGISLGLHMNQSKKD

Download         Length: 360 bp

>T100294 NZ_CP027770:c6756-6397 [Staphylococcus felis]
ATGAAGCGAGGAGACGTTTATTTAGCAGATCTCTCTCCAGTACAAGGGTCCGAACAAGGGGGAGTAAGACCCGTCGTTAT
TATTCAAAATGATACTGGAAACAAATACAGTCCAACAGTTATAGTTGCTGCTATAACAGGTAGGATTAATAAAGCTAAAA
TACCCACTCATGTTGAAATTGAAAAACAGAAATATAAGTTAGACAAAGATTCTGTTATCCTGTTAGAACAAATTAGAACA
GTAGATAAAAAGAGGCTGAAGGAGAAATTGACATATTTATCAGATGAGAAGATGAAGGAAGTCAATAATGCTCTTGGTAT
CAGCTTAGGATTGCATATGAATCAGTCTAAAAAAGACTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6337.91 Da        Isoelectric Point: 4.0644

>AT100294 WP_103207266.1 NZ_CP027770:c6927-6757 [Staphylococcus felis]
MSTFNQTRFKNNLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNESHLTNSKDD

Download         Length: 171 bp

>AT100294 NZ_CP027770:c6927-6757 [Staphylococcus felis]
ATGTCAACATTCAATCAAACAAGATTTAAAAATAATCTAGAACAGTCTTTAAAAGAAGGTTACGTACAAATGGCTGACCT
AAATCTCTCCCTAGCAACCGAAGCCTACTCAGTAGAATGTGAAGCTTGTGACTGTAACGAATCTCACTTAACGAATAGCA
AGGATGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References