Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 773635..774134 Replicon chromosome
Accession NZ_CP027768
Organism Tetragenococcus halophilus strain LMG 26042

Toxin (Protein)


Gene name relE Uniprot ID A0A091C6L0
Locus tag C7H83_RS03885 Protein ID WP_014123805.1
Coordinates 773865..774134 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A091CDY2
Locus tag C7H83_RS03880 Protein ID WP_014123804.1
Coordinates 773635..773868 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7H83_RS03850 769486..769668 + 183 WP_010620812.1 SHOCT domain-containing protein -
C7H83_RS03855 769680..769943 + 264 WP_017866944.1 SHOCT domain-containing protein -
C7H83_RS03860 769972..770229 + 258 Protein_725 DUF302 domain-containing protein -
C7H83_RS03865 770469..771095 + 627 WP_068710712.1 methyltransferase domain-containing protein -
C7H83_RS03870 771322..771552 + 231 Protein_727 DUF302 domain-containing protein -
C7H83_RS03875 772134..773423 + 1290 WP_094244185.1 group II intron reverse transcriptase/maturase -
C7H83_RS03880 773635..773868 + 234 WP_014123804.1 hypothetical protein Antitoxin
C7H83_RS03885 773865..774134 + 270 WP_014123805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7H83_RS03890 774567..774845 + 279 WP_123985479.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
C7H83_RS03895 775266..775667 - 402 WP_014123807.1 type II toxin-antitoxin system HicB family antitoxin -
C7H83_RS03900 775706..775897 - 192 WP_028790511.1 type II toxin-antitoxin system HicA family toxin -
C7H83_RS03905 776027..777088 + 1062 WP_123985480.1 acetamidase/formamidase family protein -
C7H83_RS03910 777250..778077 + 828 WP_103892908.1 hypothetical protein -
C7H83_RS03915 778145..778615 - 471 WP_103892907.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10511.30 Da        Isoelectric Point: 10.8418

>T100292 WP_014123805.1 NZ_CP027768:773865-774134 [Tetragenococcus halophilus]
MTFHVETTRRFDKQLKKLDKFAANTILKWLDKNIEGSNNPRLMGKPLVGNHSGKWRYRIGSYRVITKVDDEKLIILALEV
GHRKDIYRK

Download         Length: 270 bp

>T100292 NZ_CP027768:773865-774134 [Tetragenococcus halophilus]
ATGACTTTTCATGTAGAGACAACTCGTAGGTTCGATAAGCAATTAAAAAAATTAGACAAATTTGCTGCAAACACTATACT
TAAGTGGCTTGATAAAAATATTGAAGGAAGCAATAATCCAAGATTGATGGGTAAACCGCTCGTTGGAAATCACTCTGGGA
AATGGCGCTATCGAATAGGAAGTTATCGTGTGATTACCAAGGTTGACGACGAAAAATTAATTATTTTAGCCTTAGAAGTG
GGACACAGGAAAGATATTTATAGAAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8599.41 Da        Isoelectric Point: 3.8597

>AT100292 WP_014123804.1 NZ_CP027768:773635-773868 [Tetragenococcus halophilus]
MATITVRVTDEEKDFLDNMAKFEGKSLSELLKTTTLSSLEDAYDAQIGDAAYDEYLKNPQSRPLSESLEEYGLGESE

Download         Length: 234 bp

>AT100292 NZ_CP027768:773635-773868 [Tetragenococcus halophilus]
ATGGCTACTATTACTGTACGCGTTACTGATGAAGAAAAAGATTTTTTAGATAATATGGCAAAGTTTGAGGGAAAGAGTTT
GTCTGAACTATTAAAGACTACAACACTGTCATCTTTAGAAGACGCCTATGATGCACAAATTGGGGATGCAGCTTATGATG
AGTATTTGAAAAATCCGCAATCCCGTCCTCTGTCAGAATCATTAGAGGAATACGGCTTAGGAGAGAGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A091C6L0

Antitoxin

Source ID Structure
AlphaFold DB A0A091CDY2

References