Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 757916..758415 Replicon chromosome
Accession NZ_CP027768
Organism Tetragenococcus halophilus strain LMG 26042

Toxin (Protein)


Gene name relE Uniprot ID A0A2H6CIH1
Locus tag C7H83_RS03775 Protein ID WP_028790514.1
Coordinates 758146..758415 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2H6CIE0
Locus tag C7H83_RS03770 Protein ID WP_028790515.1
Coordinates 757916..758149 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7H83_RS03740 753407..753862 + 456 WP_103892963.1 PTS sugar transporter subunit IIA -
C7H83_RS03745 753881..754183 + 303 WP_103892964.1 PTS sugar transporter subunit IIB -
C7H83_RS03750 754199..755557 + 1359 WP_103892965.1 PTS galactitol transporter subunit IIC -
C7H83_RS03755 755538..755780 + 243 WP_103892966.1 hypothetical protein -
C7H83_RS03760 755793..756542 + 750 WP_103892967.1 class II aldolase/adducin family protein -
C7H83_RS03765 756779..757729 + 951 WP_103892968.1 acetamidase/formamidase family protein -
C7H83_RS03770 757916..758149 + 234 WP_028790515.1 toxin-antitoxin system antitoxin component Antitoxin
C7H83_RS03775 758146..758415 + 270 WP_028790514.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7H83_RS03780 758849..759127 + 279 WP_123985476.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
C7H83_RS03785 759551..759952 - 402 WP_014123807.1 type II toxin-antitoxin system HicB family antitoxin -
C7H83_RS03790 759991..760182 - 192 WP_028790511.1 type II toxin-antitoxin system HicA family toxin -
C7H83_RS03795 760312..761262 + 951 WP_123985477.1 acetamidase/formamidase family protein -
C7H83_RS03805 761819..763108 + 1290 WP_123985541.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10466.29 Da        Isoelectric Point: 10.7843

>T100291 WP_028790514.1 NZ_CP027768:758146-758415 [Tetragenococcus halophilus]
MTFHVETTPRFDKQLKKLDKFAAKTILKWLDKNIEGSNNPRLMGKPLVGNHSGKWRYRIGSYRVITKVDDEKLIILALEV
GHRKDIYRK

Download         Length: 270 bp

>T100291 NZ_CP027768:758146-758415 [Tetragenococcus halophilus]
ATGACTTTTCATGTAGAGACAACTCCTAGGTTCGATAAGCAATTAAAAAAATTAGATAAATTTGCTGCAAAAACTATACT
TAAGTGGCTTGATAAAAATATTGAAGGAAGCAATAATCCAAGATTGATGGGTAAACCGCTCGTTGGAAATCACTCTGGGA
AATGGCGTTATCGAATAGGAAGTTATCGCGTTATTACCAAGGTTGACGACGAAAAATTAATTATTTTAGCTTTAGAAGTA
GGGCACAGGAAAGATATTTATAGAAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8580.36 Da        Isoelectric Point: 3.8595

>AT100291 WP_028790515.1 NZ_CP027768:757916-758149 [Tetragenococcus halophilus]
MATITVRVTDEEKDFLDNMAKFEGKSLSELLKTTTLSSLEDAYDAQIGDAAYDEYLKNPQSHPLSESLEEYGLGESE

Download         Length: 234 bp

>AT100291 NZ_CP027768:757916-758149 [Tetragenococcus halophilus]
ATGGCTACTATTACTGTACGTGTTACTGATGAAGAAAAAGACTTTTTAGATAATATGGCAAAGTTTGAGGGAAAGAGTTT
GTCTGAACTATTAAAGACTACAACACTGTCATCTTTAGAAGACGCCTATGATGCACAAATTGGGGATGCAGCTTATGATG
AGTATTTGAAAAATCCGCAATCCCATCCTCTGTCAGAATCATTAGAGGAATATGGCTTAGGAGAGAGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H6CIH1

Antitoxin

Source ID Structure
AlphaFold DB A0A2H6CIE0

References