Detailed information of TA system TA100260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 3743682..3744295
• Replicon: chromosome
• Accession: NZ_CP027762
• Organism: Pseudomonas sp. LBUM920

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C4J83_RS17325
• Protein ID: WP_124417734.1
• Coordinates: 3743682..3743933 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4J83_RS17330
• Protein ID: WP_124417735.1
• Coordinates: 3743930..3744295 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J83_RS17325	3743682..3743933	+	252	WP_124417734.1	type II toxin-antitoxin system HicA family toxin	Toxin
C4J83_RS17330	3743930..3744295	+	366	WP_124417735.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4J83_RS17335	3744296..3745468	-	1173	WP_124417736.1	MFS transporter	-
C4J83_RS17340	3745610..3746209	+	600	WP_124417737.1	TetR/AcrR family transcriptional regulator	-
C4J83_RS17345	3746193..3747548	-	1356	WP_106579718.1	MATE family efflux transporter	-
C4J83_RS17350	3747574..3748146	-	573	WP_124417738.1	DUF2239 family protein	-
C4J83_RS17355	3748214..3749170	-	957	WP_124417739.1	ATP-dependent Clp protease ATP-binding subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9610.11 Da
• Isoelectric Point: 9.6572

>T100260 WP_124417734.1 NZ_CP027762:3743682-3743933 [Pseudomonas sp. LBUM920]
VSKNEKLLAKLLNERVAFTWQELETLLKRLGYTQIEGAGSRVKFDIDDPSAMITLHRPHPGNELKHYIRRQIIEQLKSGD
LIQ

Nucleotide

• Length: 252 bp

>T100260 NZ_CP027762:3743682-3743933 [Pseudomonas sp. LBUM920]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAACGAGCGCGTGGCCTTTACCTGGCAAGAGCTCGAAACGCTGCT
CAAGCGTCTTGGCTACACACAGATTGAAGGGGCTGGAAGCCGCGTCAAATTCGACATCGACGACCCCAGTGCAATGATCA
CCTTGCACAGGCCTCACCCCGGAAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAC
CTGATTCAGTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13224.10 Da
• Isoelectric Point: 6.9479

>AT100260 WP_124417735.1 NZ_CP027762:3743930-3744295 [Pseudomonas sp. LBUM920]
VNNQLKHNGYIGSIEASLEDNCLFGKVLFIKALVSYEGKTVAELDSAFREAVDDYLATCLRLGQTPEKPCKGSFNVRVGH
DLHLAAALAAARKKVTLNDLTRQALNEFLQHHCAEPFPAVG

Nucleotide

• Length: 366 bp

>AT100260 NZ_CP027762:3743930-3744295 [Pseudomonas sp. LBUM920]
GTGAACAACCAACTGAAACACAACGGCTACATCGGCTCTATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAAGT
GCTGTTTATCAAGGCGCTGGTCAGCTATGAAGGCAAAACCGTCGCGGAGCTGGACAGCGCTTTTCGGGAAGCCGTGGATG
ACTATCTCGCTACGTGCCTGCGCCTGGGGCAAACGCCGGAAAAGCCGTGCAAGGGTTCATTCAACGTGCGGGTCGGCCAT
GACCTGCATCTGGCTGCAGCCCTGGCAGCGGCCCGTAAGAAAGTGACGCTCAATGACCTGACGCGCCAGGCGCTGAATGA
GTTTTTGCAACATCATTGCGCAGAACCTTTTCCGGCAGTCGGCTGA