Detailed information of TA system TA100252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 1552028..1552541
• Replicon: chromosome
• Accession: NZ_CP027761
• Organism: Pseudomonas sp. R11-23-07

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C4J84_RS06930
• Protein ID: WP_124361707.1
• Coordinates: 1552028..1552312 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C4J84_RS06935
• Protein ID: WP_124361708.1
• Coordinates: 1552302..1552541 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J84_RS06905	1547259..1548407	+	1149	WP_124369936.1	L-threonine dehydrogenase	-
C4J84_RS06910	1548499..1549173	+	675	WP_124369937.1	NAD-dependent epimerase/dehydratase family protein	-
C4J84_RS06915	1549266..1550459	+	1194	WP_124435085.1	CoA transferase	-
C4J84_RS06920	1550546..1551034	-	489	WP_124369938.1	DMT family transporter	-
C4J84_RS06925	1551103..1552020	+	918	WP_124435086.1	LysR family transcriptional regulator	-
C4J84_RS06930	1552028..1552312	-	285	WP_124361707.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C4J84_RS06935	1552302..1552541	-	240	WP_124361708.1	ribbon-helix-helix protein, CopG family	Antitoxin
C4J84_RS06940	1552642..1553052	+	411	WP_124369940.1	fosfomycin resistance glutathione transferase	-
C4J84_RS06945	1553222..1553749	+	528	WP_057723086.1	DUF4142 domain-containing protein	-
C4J84_RS06950	1553820..1554245	-	426	WP_124435087.1	low affinity iron permease family protein	-
C4J84_RS06955	1554421..1555203	+	783	WP_124435088.1	GNAT family N-acetyltransferase	-
C4J84_RS06960	1555204..1555704	-	501	WP_124435089.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
C4J84_RS06970	1556120..1557004	-	885	WP_124435090.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11014.73 Da
• Isoelectric Point: 10.1506

>T100252 WP_124361707.1 NZ_CP027761:c1552312-1552028 [Pseudomonas sp. R11-23-07]
MQVEWLRTALRNLDDEAAFIAEENPKAAYEFVQAILAGLEHIAQFPALGKTGRVPGTREWVVPRWPYIVPYRIREGRLQV
MRIFHTRRQPPTSW

Nucleotide

• Length: 285 bp

>T100252 NZ_CP027761:c1552312-1552028 [Pseudomonas sp. R11-23-07]
ATGCAGGTTGAGTGGCTGAGGACAGCCCTCAGAAACCTGGATGATGAAGCGGCCTTTATTGCTGAAGAAAACCCTAAAGC
CGCCTACGAGTTCGTCCAGGCGATTTTGGCCGGGCTTGAACACATTGCGCAATTTCCCGCGTTGGGAAAAACCGGGCGCG
TCCCAGGGACGCGTGAATGGGTGGTGCCCCGGTGGCCCTACATTGTCCCTTACCGTATTCGTGAAGGGCGACTACAGGTG
ATGCGAATTTTTCATACCCGCCGCCAACCACCTACCTCCTGGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8597.72 Da
• Isoelectric Point: 4.7571

>AT100252 WP_124361708.1 NZ_CP027761:c1552541-1552302 [Pseudomonas sp. R11-23-07]
MSVMSLRIPDDVADTLASLAKATGRSKSFLAVDALREYLTREAWQIEEIQKALKEADAGDFATAAEVKAVADKWRNNAG

Nucleotide

• Length: 240 bp

>AT100252 NZ_CP027761:c1552541-1552302 [Pseudomonas sp. R11-23-07]
ATGTCTGTTATGTCCCTGCGGATACCGGACGATGTCGCCGATACGCTTGCCAGTCTGGCCAAAGCGACCGGTCGCAGCAA
ATCGTTCCTCGCTGTTGACGCGCTACGTGAATACTTGACGCGTGAAGCATGGCAAATCGAAGAGATTCAAAAGGCGCTGA
AAGAAGCTGATGCGGGGGATTTCGCGACGGCTGCCGAGGTAAAAGCCGTCGCTGACAAATGGCGCAACAATGCAGGTTGA