Detailed information of TA system TA100250

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 962131..962770
• Replicon: chromosome
• Accession: NZ_CP027761
• Organism: Pseudomonas sp. R11-23-07

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C4J84_RS04170
• Protein ID: WP_124369634.1
• Coordinates: 962131..962313 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4J84_RS04175
• Protein ID: WP_124369635.1
• Coordinates: 962369..962770 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J84_RS04155	958019..960304	-	2286	WP_124434958.1	TonB-dependent siderophore receptor	-
C4J84_RS04160	960510..961190	+	681	WP_124361261.1	Fe2+-dependent dioxygenase	-
C4J84_RS04165	961192..961941	+	750	WP_124369633.1	sel1 repeat family protein	-
C4J84_RS04170	962131..962313	+	183	WP_124369634.1	type II toxin-antitoxin system HicA family toxin	Toxin
C4J84_RS04175	962369..962770	+	402	WP_124369635.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4J84_RS04180	962846..964009	-	1164	WP_124361263.1	type III PLP-dependent enzyme	-
C4J84_RS04185	964478..965635	-	1158	WP_124369636.1	ABC transporter ATP-binding protein	-
C4J84_RS04190	965632..966285	-	654	WP_124361264.1	ABC transporter permease	-
C4J84_RS04195	966297..967193	-	897	WP_124369637.1	glycine betaine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6756.89 Da
• Isoelectric Point: 11.3464

>T100250 WP_124369634.1 NZ_CP027761:962131-962313 [Pseudomonas sp. R11-23-07]
MRSREVIELLVADGWFEVAVKGSHHQFKHPVKRGRVTVPHPKSELAKGTLHSIFRSAGLK

Nucleotide

• Length: 183 bp

>T100250 NZ_CP027761:962131-962313 [Pseudomonas sp. R11-23-07]
ATGAGAAGTCGAGAGGTGATTGAGCTACTGGTGGCGGACGGTTGGTTTGAGGTGGCGGTGAAGGGTAGTCATCACCAATT
CAAACATCCAGTGAAGCGAGGGCGGGTGACGGTCCCTCATCCCAAGTCAGAACTTGCAAAGGGCACTCTGCATAGTATTT
TCAGATCGGCAGGCCTGAAATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14509.39 Da
• Isoelectric Point: 4.3897

>AT100250 WP_124369635.1 NZ_CP027761:962369-962770 [Pseudomonas sp. R11-23-07]
MKFPVVVHKDADSDYSVTVPDIPGCFSAGGSFSEALDNVREAIALHLEGLVADQEVLPQALEVDAHLDNPDFVGGVWAIV
DFDLTPYLGKSVRFNASLPEQLLLRIDERVLKDHRYASRSGFLATAALRELSA

Nucleotide

• Length: 402 bp

>AT100250 NZ_CP027761:962369-962770 [Pseudomonas sp. R11-23-07]
ATGAAATTTCCCGTGGTAGTCCATAAAGATGCTGATTCGGATTACAGCGTGACGGTTCCGGATATTCCGGGATGTTTCTC
GGCCGGAGGATCTTTTTCCGAAGCGCTGGACAATGTGCGTGAGGCGATCGCGCTGCATCTGGAAGGATTGGTTGCCGATC
AGGAAGTGCTCCCCCAGGCGCTGGAGGTCGATGCACATTTGGATAATCCGGATTTTGTCGGCGGTGTATGGGCGATAGTC
GACTTTGATCTCACGCCTTATCTGGGCAAGTCAGTCCGTTTTAACGCTTCCTTGCCGGAACAGTTGCTGTTGCGCATTGA
CGAGCGGGTGCTGAAGGATCATCGGTATGCGTCGCGGTCAGGTTTTCTGGCGACGGCAGCGCTGCGTGAGCTATCTGCCT
GA