100248

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4826432..4827474 Replicon chromosome
Accession NZ_CP027760
Organism Pseudomonas sp. R4-34-07

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag C4J85_RS22235 Protein ID WP_124371779.1
Coordinates 4826432..4827007 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag C4J85_RS22240 Protein ID WP_124405219.1
Coordinates 4827004..4827474 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J85_RS22195 4821504..4821839 + 336 WP_124410710.1 hypothetical protein -
C4J85_RS22200 4821910..4822260 - 351 WP_124405846.1 hypothetical protein -
C4J85_RS22205 4822472..4822801 + 330 WP_124405215.1 hypothetical protein -
C4J85_RS22210 4822763..4823410 - 648 WP_124410711.1 LysE family transporter -
C4J85_RS22215 4823436..4824242 - 807 WP_124410712.1 2OG-Fe(II) oxygenase family protein -
C4J85_RS22220 4824476..4825168 + 693 WP_124411224.1 helix-turn-helix domain-containing protein -
C4J85_RS22225 4825170..4825805 - 636 WP_124410713.1 LysE family translocator -
C4J85_RS22230 4825942..4826313 + 372 WP_124405218.1 PH domain-containing protein -
C4J85_RS22235 4826432..4827007 - 576 WP_124371779.1 PIN domain-containing protein Toxin
C4J85_RS22240 4827004..4827474 - 471 WP_124405219.1 helix-turn-helix domain-containing protein Antitoxin
C4J85_RS22245 4827660..4828823 + 1164 WP_124410714.1 S-type pyocin domain-containing protein -
C4J85_RS22250 4828838..4829125 + 288 WP_124410715.1 cloacin -
C4J85_RS22255 4829142..4829585 + 444 Protein_4299 hypothetical protein -
C4J85_RS22260 4829659..4830033 - 375 WP_124410716.1 cytochrome c family protein -
C4J85_RS22265 4830259..4830639 + 381 WP_124364322.1 response regulator -
C4J85_RS22270 4830833..4831447 + 615 WP_124410717.1 biliverdin-producing heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4820253..4830639 10386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21699.18 Da        Isoelectric Point: 5.0478

>T100248 WP_124371779.1 NZ_CP027760:c4827007-4826432 [Pseudomonas sp. R4-34-07]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTRQIHEEWKRNVLKNRPDLTPDQVDKISALMDKAIPDALVTGY
EDLCSSLDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPVRVLAAYDIEPMHPDDFISDLWDLDQAAVLAAVQKQRRALVR
PPMNGEGYLEMLMRQGLVQTSKLLGPYEVML

Download         Length: 576 bp

>T100248 NZ_CP027760:c4827007-4826432 [Pseudomonas sp. R4-34-07]
ATGAGATGTTCGCCTTTCACTGCGGTTTACGACGCCTGTGTTCTGTACCCGGCGGCTCTCAGGGATTTGTTGATGTGGCT
TGGTTTATCCGGGTTGTACCGGGCGCGATGGACCCGACAGATTCATGAAGAGTGGAAGCGTAACGTCCTCAAGAACCGAC
CTGATCTCACTCCCGACCAGGTAGATAAAATTTCGGCATTGATGGACAAGGCCATACCGGACGCGTTGGTAACAGGGTAC
GAAGACTTGTGTTCAAGTTTGGATTTGCCTGATCCAGATGATCGTCACGTACTGGCCGCGGCGATTCGGAGTAAGGCGGA
AGTTATCGTGACCTTTAACTTGAAAGACTTTCCAGTGCGAGTACTCGCGGCTTATGACATAGAACCGATGCATCCCGACG
ACTTTATCTCGGACCTTTGGGACTTGGATCAAGCGGCCGTGTTGGCGGCAGTGCAGAAGCAGAGGCGTGCACTGGTTAGG
CCGCCGATGAATGGGGAAGGGTATCTCGAGATGTTGATGCGGCAGGGGCTAGTGCAGACCAGTAAGCTGCTTGGGCCTTA
TGAGGTAATGTTGTAG

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17661.30 Da        Isoelectric Point: 5.6533

>AT100248 WP_124405219.1 NZ_CP027760:c4827474-4827004 [Pseudomonas sp. R4-34-07]
MITNHLPKTIPPLEKEVEAAVQGQRELASLLSTKFETQRIDIFDKEDKPHTLVLPTSALRLLVDILGELALGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEEGAIPFTKTGRHRRIRFSDLMAFKQRRDEESQEAMEELVRQTRELGLGYDE

Download         Length: 471 bp

>AT100248 NZ_CP027760:c4827474-4827004 [Pseudomonas sp. R4-34-07]
ATGATCACCAATCACCTTCCCAAAACAATTCCTCCGCTGGAAAAGGAAGTCGAAGCCGCTGTGCAAGGCCAACGCGAGCT
GGCTTCGTTGCTATCGACCAAATTCGAAACCCAGCGCATCGACATCTTCGACAAAGAAGACAAGCCCCACACCCTTGTAC
TCCCCACATCCGCGCTGCGCCTGCTGGTTGATATTTTGGGTGAGCTGGCGCTGGGTAATGCCGTCAAAGTTGTACCCGTC
CATGCTGAATTGACCTCCCAGGAAGCTGCCGACCTGCTTAACGTTTCACGCCCGCATCTGGTCAAGATGCTTGAAGAAGG
CGCCATTCCCTTTACGAAGACCGGTCGTCATCGGCGTATTCGATTTTCCGATTTGATGGCGTTCAAACAGCGCCGCGATG
AAGAAAGTCAAGAGGCGATGGAGGAACTGGTACGGCAGACCCGGGAGTTGGGATTGGGGTATGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References