Detailed information of TA system TA100242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 1500334..1500847
• Replicon: chromosome
• Accession: NZ_CP027760
• Organism: Pseudomonas sp. R4-34-07

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C4J85_RS06760
• Protein ID: WP_124361707.1
• Coordinates: 1500334..1500618 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C4J85_RS06765
• Protein ID: WP_124361708.1
• Coordinates: 1500608..1500847 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J85_RS06735	1495647..1496453	-	807	WP_124409276.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
C4J85_RS06740	1496806..1497480	+	675	WP_124409277.1	NAD-dependent epimerase/dehydratase family protein	-
C4J85_RS06745	1497573..1498766	+	1194	WP_124409278.1	CoA transferase	-
C4J85_RS06750	1498853..1499341	-	489	WP_124369938.1	DMT family transporter	-
C4J85_RS06755	1499409..1500326	+	918	WP_124409279.1	LysR family transcriptional regulator	-
C4J85_RS06760	1500334..1500618	-	285	WP_124361707.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C4J85_RS06765	1500608..1500847	-	240	WP_124361708.1	ribbon-helix-helix protein, CopG family	Antitoxin
C4J85_RS06770	1500948..1501358	+	411	WP_124366196.1	fosfomycin resistance glutathione transferase	-
C4J85_RS06775	1501528..1502055	+	528	WP_057723086.1	DUF4142 domain-containing protein	-
C4J85_RS06780	1502109..1502531	-	423	WP_124406519.1	low affinity iron permease family protein	-
C4J85_RS06785	1502708..1503490	+	783	WP_124409280.1	GNAT family N-acetyltransferase	-
C4J85_RS06790	1503491..1503991	-	501	WP_124361714.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
C4J85_RS06795	1504091..1504423	-	333	WP_124406521.1	hypothetical protein	-
C4J85_RS06805	1504828..1505712	-	885	WP_124369943.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11014.73 Da
• Isoelectric Point: 10.1506

>T100242 WP_124361707.1 NZ_CP027760:c1500618-1500334 [Pseudomonas sp. R4-34-07]
MQVEWLRTALRNLDDEAAFIAEENPKAAYEFVQAILAGLEHIAQFPALGKTGRVPGTREWVVPRWPYIVPYRIREGRLQV
MRIFHTRRQPPTSW

Nucleotide

• Length: 285 bp

>T100242 NZ_CP027760:c1500618-1500334 [Pseudomonas sp. R4-34-07]
ATGCAGGTTGAGTGGCTGAGGACAGCCCTCAGAAACCTGGATGATGAAGCGGCCTTTATTGCTGAAGAAAACCCCAAAGC
CGCCTACGAGTTCGTCCAGGCGATTTTGGCCGGGCTTGAACACATTGCGCAATTTCCCGCGCTGGGAAAAACCGGGCGCG
TCCCAGGGACGCGTGAATGGGTGGTGCCCCGGTGGCCCTACATTGTCCCTTACCGTATTCGTGAAGGGCGACTACAGGTG
ATGCGAATTTTTCATACCCGCCGCCAACCACCGACCTCCTGGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8597.72 Da
• Isoelectric Point: 4.7571

>AT100242 WP_124361708.1 NZ_CP027760:c1500847-1500608 [Pseudomonas sp. R4-34-07]
MSVMSLRIPDDVADTLASLAKATGRSKSFLAVDALREYLTREAWQIEEIQKALKEADAGDFATAAEVKAVADKWRNNAG

Nucleotide

• Length: 240 bp

>AT100242 NZ_CP027760:c1500847-1500608 [Pseudomonas sp. R4-34-07]
ATGTCTGTTATGTCCCTGCGGATACCGGACGATGTCGCCGATACGCTTGCCAGTCTGGCCAAAGCGACCGGTCGCAGCAA
ATCGTTCCTCGCTGTTGACGCGCTACGTGAATACTTGACGCGTGAAGCATGGCAAATCGAAGAGATTCAAAAGGCGCTGA
AAGAAGCTGATGCGGGGGATTTCGCGACGGCTGCCGAGGTAAAAGCCGTCGCTGACAAATGGCGCAACAATGCAGGTTGA