Detailed information of TA system TA100240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 4708050..4709092
• Replicon: chromosome
• Accession: NZ_CP027759
• Organism: Pseudomonas sp. R2-7-07

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: C4J86_RS21600
• Protein ID: WP_124371779.1
• Coordinates: 4708050..4708625 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: C4J86_RS21605
• Protein ID: WP_124371780.1
• Coordinates: 4708622..4709092 (-)
• Length: 157 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J86_RS21570	4704761..4705348	-	588	WP_124371774.1	hypothetical protein	-
C4J86_RS21575	4705560..4705799	+	240	WP_124371775.1	hypothetical protein	-
C4J86_RS21580	4705889..4706239	-	351	WP_124372472.1	hypothetical protein	-
C4J86_RS21585	4706451..4706780	+	330	WP_124371776.1	hypothetical protein	-
C4J86_RS21590	4706788..4707423	-	636	WP_124371777.1	LysE family translocator	-
C4J86_RS21595	4707560..4707931	+	372	WP_124371778.1	PH domain-containing protein	-
C4J86_RS21600	4708050..4708625	-	576	WP_124371779.1	PIN domain-containing protein	Toxin
C4J86_RS21605	4708622..4709092	-	471	WP_124371780.1	helix-turn-helix domain-containing protein	Antitoxin
C4J86_RS21610	4709277..4709543	+	267	Protein_4172	detoxification	-
C4J86_RS21615	4709599..4709886	+	288	WP_124371781.1	cloacin	-
C4J86_RS21620	4709903..4710373	+	471	WP_124372473.1	hypothetical protein	-
C4J86_RS21625	4710422..4710796	-	375	WP_124371782.1	cytochrome c family protein	-
C4J86_RS21630	4711021..4711401	+	381	WP_124371783.1	response regulator	-
C4J86_RS21635	4711595..4712209	+	615	WP_124371784.1	biliverdin-producing heme oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4698894..4710373	11479

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21699.18 Da
• Isoelectric Point: 5.0478

>T100240 WP_124371779.1 NZ_CP027759:c4708625-4708050 [Pseudomonas sp. R2-7-07]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTRQIHEEWKRNVLKNRPDLTPDQVDKISALMDKAIPDALVTGY
EDLCSSLDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPVRVLAAYDIEPMHPDDFISDLWDLDQAAVLAAVQKQRRALVR
PPMNGEGYLEMLMRQGLVQTSKLLGPYEVML

Nucleotide

• Length: 576 bp

>T100240 NZ_CP027759:c4708625-4708050 [Pseudomonas sp. R2-7-07]
ATGAGGTGTTCGCCTTTCACTGCGGTTTACGACGCCTGTGTTCTGTACCCGGCGGCTCTCAGGGATTTGTTGATGTGGCT
TGGTTTATCCGGGTTGTACCGGGCGCGATGGACCCGACAGATTCATGAAGAGTGGAAGCGTAACGTCCTCAAGAACCGAC
CTGATCTCACTCCCGACCAAGTAGATAAAATTTCGGCATTGATGGACAAGGCCATACCGGACGCGTTGGTAACAGGGTAC
GAAGACTTGTGTTCAAGTTTGGATTTGCCTGATCCAGATGATCGTCACGTATTGGCCGCGGCGATTCGGAGTAAGGCGGA
AGTTATCGTGACCTTTAACTTGAAAGATTTTCCAGTGCGGGTACTCGCGGCTTATGACATAGAACCGATGCATCCCGACG
ACTTTATCTCGGACCTTTGGGACTTGGATCAAGCGGCCGTGTTGGCGGCAGTGCAGAAGCAGAGGCGTGCACTAGTTAGG
CCGCCGATGAATGGGGAAGGGTATCTCGAGATGTTGATGCGGCAGGGGCTAGTGCAGACCAGTAAGCTGCTTGGGCCTTA
TGAGGTAATGTTGTAG

Antitoxin

Protein

• Length: 157 a.a.
• Molecular weight: 17689.32 Da
• Isoelectric Point: 5.6533

>AT100240 WP_124371780.1 NZ_CP027759:c4709092-4708622 [Pseudomonas sp. R2-7-07]
MITNHLPKTIPPLEREVEAAVQGQRELASLLSTKFETQRIDIFDKEDKPHTLVLPTSALRLLVDILGELALGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEEGAIPFTKTGRHRRIRFSDLMAFKQRRDEESQEAMEELVRQTRELGLGYDE

Nucleotide

• Length: 471 bp

>AT100240 NZ_CP027759:c4709092-4708622 [Pseudomonas sp. R2-7-07]
ATGATCACCAATCACCTTCCCAAAACAATTCCTCCGCTGGAGAGGGAAGTCGAAGCCGCTGTGCAAGGCCAACGCGAGCT
GGCTTCGTTGCTATCGACCAAATTCGAAACCCAGCGCATCGACATCTTCGACAAAGAAGACAAGCCTCACACCCTTGTAC
TCCCCACATCCGCGCTGCGCCTGCTGGTTGATATTTTGGGTGAGCTGGCGCTGGGTAATGCCGTCAAAGTTGTACCCGTC
CATGCTGAATTGACCTCTCAGGAAGCTGCCGACCTGCTTAACGTTTCACGCCCGCATCTGGTCAAGATGCTGGAAGAAGG
CGCCATTCCCTTTACGAAAACCGGTCGTCATCGGCGTATTCGATTTTCCGATTTGATGGCGTTCAAACAGCGCCGCGATG
AAGAAAGTCAAGAGGCGATGGAGGAACTGGTACGGCAGACCCGGGAGTTGGGATTGGGGTATGACGAATGA