Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4708050..4709092 Replicon chromosome
Accession NZ_CP027759
Organism Pseudomonas sp. R2-7-07

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag C4J86_RS21600 Protein ID WP_124371779.1
Coordinates 4708050..4708625 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag C4J86_RS21605 Protein ID WP_124371780.1
Coordinates 4708622..4709092 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J86_RS21570 4704761..4705348 - 588 WP_124371774.1 hypothetical protein -
C4J86_RS21575 4705560..4705799 + 240 WP_124371775.1 hypothetical protein -
C4J86_RS21580 4705889..4706239 - 351 WP_124372472.1 hypothetical protein -
C4J86_RS21585 4706451..4706780 + 330 WP_124371776.1 hypothetical protein -
C4J86_RS21590 4706788..4707423 - 636 WP_124371777.1 LysE family translocator -
C4J86_RS21595 4707560..4707931 + 372 WP_124371778.1 PH domain-containing protein -
C4J86_RS21600 4708050..4708625 - 576 WP_124371779.1 PIN domain-containing protein Toxin
C4J86_RS21605 4708622..4709092 - 471 WP_124371780.1 helix-turn-helix domain-containing protein Antitoxin
C4J86_RS21610 4709277..4709543 + 267 Protein_4172 detoxification -
C4J86_RS21615 4709599..4709886 + 288 WP_124371781.1 cloacin -
C4J86_RS21620 4709903..4710373 + 471 WP_124372473.1 hypothetical protein -
C4J86_RS21625 4710422..4710796 - 375 WP_124371782.1 cytochrome c family protein -
C4J86_RS21630 4711021..4711401 + 381 WP_124371783.1 response regulator -
C4J86_RS21635 4711595..4712209 + 615 WP_124371784.1 biliverdin-producing heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4698894..4710373 11479


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21699.18 Da        Isoelectric Point: 5.0478

>T100240 WP_124371779.1 NZ_CP027759:c4708625-4708050 [Pseudomonas sp. R2-7-07]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTRQIHEEWKRNVLKNRPDLTPDQVDKISALMDKAIPDALVTGY
EDLCSSLDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPVRVLAAYDIEPMHPDDFISDLWDLDQAAVLAAVQKQRRALVR
PPMNGEGYLEMLMRQGLVQTSKLLGPYEVML

Download         Length: 576 bp

>T100240 NZ_CP027759:c4708625-4708050 [Pseudomonas sp. R2-7-07]
ATGAGGTGTTCGCCTTTCACTGCGGTTTACGACGCCTGTGTTCTGTACCCGGCGGCTCTCAGGGATTTGTTGATGTGGCT
TGGTTTATCCGGGTTGTACCGGGCGCGATGGACCCGACAGATTCATGAAGAGTGGAAGCGTAACGTCCTCAAGAACCGAC
CTGATCTCACTCCCGACCAAGTAGATAAAATTTCGGCATTGATGGACAAGGCCATACCGGACGCGTTGGTAACAGGGTAC
GAAGACTTGTGTTCAAGTTTGGATTTGCCTGATCCAGATGATCGTCACGTATTGGCCGCGGCGATTCGGAGTAAGGCGGA
AGTTATCGTGACCTTTAACTTGAAAGATTTTCCAGTGCGGGTACTCGCGGCTTATGACATAGAACCGATGCATCCCGACG
ACTTTATCTCGGACCTTTGGGACTTGGATCAAGCGGCCGTGTTGGCGGCAGTGCAGAAGCAGAGGCGTGCACTAGTTAGG
CCGCCGATGAATGGGGAAGGGTATCTCGAGATGTTGATGCGGCAGGGGCTAGTGCAGACCAGTAAGCTGCTTGGGCCTTA
TGAGGTAATGTTGTAG

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17689.32 Da        Isoelectric Point: 5.6533

>AT100240 WP_124371780.1 NZ_CP027759:c4709092-4708622 [Pseudomonas sp. R2-7-07]
MITNHLPKTIPPLEREVEAAVQGQRELASLLSTKFETQRIDIFDKEDKPHTLVLPTSALRLLVDILGELALGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEEGAIPFTKTGRHRRIRFSDLMAFKQRRDEESQEAMEELVRQTRELGLGYDE

Download         Length: 471 bp

>AT100240 NZ_CP027759:c4709092-4708622 [Pseudomonas sp. R2-7-07]
ATGATCACCAATCACCTTCCCAAAACAATTCCTCCGCTGGAGAGGGAAGTCGAAGCCGCTGTGCAAGGCCAACGCGAGCT
GGCTTCGTTGCTATCGACCAAATTCGAAACCCAGCGCATCGACATCTTCGACAAAGAAGACAAGCCTCACACCCTTGTAC
TCCCCACATCCGCGCTGCGCCTGCTGGTTGATATTTTGGGTGAGCTGGCGCTGGGTAATGCCGTCAAAGTTGTACCCGTC
CATGCTGAATTGACCTCTCAGGAAGCTGCCGACCTGCTTAACGTTTCACGCCCGCATCTGGTCAAGATGCTGGAAGAAGG
CGCCATTCCCTTTACGAAAACCGGTCGTCATCGGCGTATTCGATTTTCCGATTTGATGGCGTTCAAACAGCGCCGCGATG
AAGAAAGTCAAGAGGCGATGGAGGAACTGGTACGGCAGACCCGGGAGTTGGGATTGGGGTATGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References