Detailed information of TA system TA100238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2509352..2509965
• Replicon: chromosome
• Accession: NZ_CP027759
• Organism: Pseudomonas sp. R2-7-07

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C4J86_RS11545
• Protein ID: WP_124370470.1
• Coordinates: 2509714..2509965 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4J86_RS11540
• Protein ID: WP_124362545.1
• Coordinates: 2509352..2509717 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J86_RS26910	2505316..2506560	+	1245	WP_177412745.1	hypothetical protein	-
C4J86_RS11530	2506785..2508140	+	1356	WP_124362543.1	MATE family efflux transporter	-
C4J86_RS11535	2508180..2509385	+	1206	WP_124370469.1	MFS transporter	-
C4J86_RS11540	2509352..2509717	-	366	WP_124362545.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4J86_RS11545	2509714..2509965	-	252	WP_124370470.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9476.01 Da
• Isoelectric Point: 10.0459

>T100238 WP_124370470.1 NZ_CP027759:c2509965-2509714 [Pseudomonas sp. R2-7-07]
VSKNEKLLAKLLNEHMAFTWSELVTLLRRLGYTQIEGAGSRVKFDIGDPSALITLHKPHPGNELKHYIRRQIIEQLKSGE
LVQ

Nucleotide

• Length: 252 bp

>T100238 NZ_CP027759:c2509965-2509714 [Pseudomonas sp. R2-7-07]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAATGAGCACATGGCATTCACCTGGTCTGAACTCGTAACCCTGTT
ACGGCGACTGGGTTACACACAGATTGAAGGGGCTGGAAGCCGGGTCAAATTCGACATTGGCGACCCCAGTGCACTGATCA
CCTTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAAATCATCGAACAATTGAAATCAGGAGAA
CTGGTTCAGTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13208.01 Da
• Isoelectric Point: 6.7400

>AT100238 WP_124362545.1 NZ_CP027759:c2509717-2509352 [Pseudomonas sp. R2-7-07]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFQEAVDDYLATCQSLGQTPEKPCKGSFNVRVGH
DLHLAAALAANRKKVTLNDLTRQALDEFLHHHFPQPCAATG

Nucleotide

• Length: 366 bp

>AT100238 NZ_CP027759:c2509717-2509352 [Pseudomonas sp. R2-7-07]
GTGAACAACCAGCTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAGGACAACTGCCTGTTCGGCAAAAT
CCTGTTCATCAAGGCCCTGGTGAGCTACGAAGGCAAGACTGTCGCAGAGTTGGACGCGGCCTTCCAAGAGGCGGTGGACG
ATTACCTCGCCACCTGCCAGTCGCTCGGGCAAACTCCTGAAAAGCCATGCAAGGGCTCGTTCAACGTACGCGTTGGCCAT
GACCTGCATCTGGCGGCAGCGTTGGCGGCGAACCGCAAGAAAGTGACGTTGAACGACCTGACACGCCAGGCGCTGGATGA
GTTTCTACACCATCATTTCCCGCAGCCTTGCGCGGCGACCGGCTGA