Detailed information of TA system TA100233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1054607..1055246
• Replicon: chromosome
• Accession: NZ_CP027759
• Organism: Pseudomonas sp. R2-7-07

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C4J86_RS04610
• Protein ID: WP_124369634.1
• Coordinates: 1054607..1054789 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4J86_RS04615
• Protein ID: WP_124369635.1
• Coordinates: 1054845..1055246 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J86_RS04595	1050495..1052780	-	2286	WP_124369631.1	TonB-dependent siderophore receptor	-
C4J86_RS04600	1052986..1053666	+	681	WP_124369632.1	Fe2+-dependent dioxygenase	-
C4J86_RS04605	1053668..1054417	+	750	WP_124369633.1	sel1 repeat family protein	-
C4J86_RS04610	1054607..1054789	+	183	WP_124369634.1	type II toxin-antitoxin system HicA family toxin	Toxin
C4J86_RS04615	1054845..1055246	+	402	WP_124369635.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4J86_RS04620	1055322..1056485	-	1164	WP_124361263.1	type III PLP-dependent enzyme	-
C4J86_RS04625	1056954..1058111	-	1158	WP_124369636.1	ABC transporter ATP-binding protein	-
C4J86_RS04630	1058108..1058761	-	654	WP_124361264.1	ABC transporter permease	-
C4J86_RS04635	1058773..1059669	-	897	WP_124369637.1	glycine betaine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6756.89 Da
• Isoelectric Point: 11.3464

>T100233 WP_124369634.1 NZ_CP027759:1054607-1054789 [Pseudomonas sp. R2-7-07]
MRSREVIELLVADGWFEVAVKGSHHQFKHPVKRGRVTVPHPKSELAKGTLHSIFRSAGLK

Nucleotide

• Length: 183 bp

>T100233 NZ_CP027759:1054607-1054789 [Pseudomonas sp. R2-7-07]
ATGAGAAGTCGAGAGGTGATTGAGCTACTGGTGGCGGACGGTTGGTTTGAGGTGGCGGTGAAGGGTAGTCATCACCAATT
CAAACATCCAGTGAAGCGAGGGCGGGTGACGGTCCCTCATCCCAAGTCAGAACTTGCAAAGGGCACTCTGCATAGTATTT
TCAGATCGGCAGGCCTGAAATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14509.39 Da
• Isoelectric Point: 4.3897

>AT100233 WP_124369635.1 NZ_CP027759:1054845-1055246 [Pseudomonas sp. R2-7-07]
MKFPVVVHKDADSDYSVTVPDIPGCFSAGGSFSEALDNVREAIALHLEGLVADQEVLPQALEVDAHLDNPDFVGGVWAIV
DFDLTPYLGKSVRFNASLPEQLLLRIDERVLKDHRYASRSGFLATAALRELSA

Nucleotide

• Length: 402 bp

>AT100233 NZ_CP027759:1054845-1055246 [Pseudomonas sp. R2-7-07]
ATGAAATTTCCCGTGGTAGTCCATAAAGATGCTGATTCGGATTACAGCGTGACGGTTCCGGATATTCCGGGATGTTTCTC
GGCCGGAGGATCTTTTTCCGAAGCGCTGGACAATGTGCGTGAGGCGATCGCGCTGCATCTGGAAGGATTGGTTGCCGATC
AGGAAGTGCTCCCCCAGGCGCTGGAGGTCGATGCACATTTGGATAATCCGGATTTTGTCGGCGGTGTATGGGCGATAGTC
GACTTTGATCTCACGCCTTATCTGGGCAAGTCAGTCCGTTTTAACGCTTCCTTGCCGGAACAGTTGCTGTTGCGCATTGA
CGAGCGGGTGCTGAAGGATCATCGGTATGCGTCGCGGTCAGGTTTTCTGGCGACGGCAGCGCTGCGTGAGCTATCTGCCT
GA