100222

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2535134..2535687 Replicon chromosome
Accession NZ_CP027757
Organism Pseudomonas synxantha strain R2-4-08W

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag C4K00_RS11435 Protein ID WP_124412064.1
Coordinates 2535394..2535687 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C4K00_RS11430 Protein ID WP_124412063.1
Coordinates 2535134..2535406 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K00_RS11405 2530725..2531231 + 507 WP_206425763.1 GNAT family N-acetyltransferase -
C4K00_RS11410 2531410..2532348 - 939 WP_046072181.1 GlxA family transcriptional regulator -
C4K00_RS11415 2532521..2533150 + 630 WP_124412061.1 TetR/AcrR family transcriptional regulator -
C4K00_RS11420 2533147..2533824 + 678 WP_124400334.1 type 1 glutamine amidotransferase domain-containing protein -
C4K00_RS11425 2533903..2535030 + 1128 WP_124412062.1 alkene reductase -
C4K00_RS11430 2535134..2535406 + 273 WP_124412063.1 CopG family ribbon-helix-helix protein Antitoxin
C4K00_RS11435 2535394..2535687 + 294 WP_124412064.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K00_RS11440 2535692..2536690 - 999 WP_124412065.1 NAD(P)H-quinone oxidoreductase -
C4K00_RS11445 2536687..2537919 - 1233 WP_124412066.1 YbfB/YjiJ family MFS transporter -
C4K00_RS11450 2538031..2538906 + 876 WP_124412067.1 LysR family transcriptional regulator -
C4K00_RS11455 2538987..2539373 + 387 WP_057022649.1 DoxX family protein -
C4K00_RS11460 2539428..2540246 - 819 WP_124412068.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10938.60 Da        Isoelectric Point: 6.9784

>T100222 WP_124412064.1 NZ_CP027757:2535394-2535687 [Pseudomonas synxantha]
VPRLIITATALAGLERCRQFLTEKDPQVARRAAQTINSQLLRLEFDPNIGRPYDELPELRELVIAFGDAGYVALYRVIPS
ESAVLVLAFRHQREAGY

Download         Length: 294 bp

>T100222 NZ_CP027757:2535394-2535687 [Pseudomonas synxantha]
GTGCCACGATTGATCATTACTGCAACGGCGCTGGCAGGCTTAGAACGCTGCCGGCAGTTCTTGACGGAAAAAGATCCGCA
GGTCGCACGCAGGGCCGCCCAGACAATCAATAGCCAGCTGCTCCGTCTGGAATTCGATCCCAATATAGGCCGACCCTATG
ACGAGTTGCCCGAGTTGCGAGAGCTGGTAATCGCTTTCGGGGATGCCGGTTATGTGGCGTTATACCGCGTCATCCCTTCA
GAATCGGCGGTATTGGTATTGGCCTTCCGGCATCAGCGAGAAGCGGGCTACTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10426.58 Da        Isoelectric Point: 6.0787

>AT100222 WP_124412063.1 NZ_CP027757:2535134-2535406 [Pseudomonas synxantha]
MATSIKIDDDLKHRIQLLAGARQRTAHWIMREALSQYVEREEARESFKQEALSSWKNYQETGLHVTGSEARAWLDTWGTE
QASEPPKCHD

Download         Length: 273 bp

>AT100222 NZ_CP027757:2535134-2535406 [Pseudomonas synxantha]
ATGGCAACGTCTATCAAAATCGATGATGACTTGAAGCATCGCATTCAGTTGCTAGCCGGTGCGCGGCAGCGTACCGCTCA
TTGGATTATGCGTGAGGCTCTCTCACAGTATGTGGAGCGAGAAGAGGCACGCGAGAGCTTCAAGCAGGAAGCGTTGTCGT
CTTGGAAGAACTACCAGGAAACGGGCTTGCATGTCACCGGCTCCGAGGCTCGAGCCTGGCTTGACACTTGGGGGACTGAG
CAAGCGTCGGAGCCACCCAAGTGCCACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References