Detailed information of TA system TA100210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 1743895..1744408
• Replicon: chromosome
• Accession: NZ_CP027756
• Organism: Pseudomonas synxantha strain R6-28-08

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C4K01_RS08035
• Protein ID: WP_082636613.1
• Coordinates: 1743895..1744179 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C4K01_RS08040
• Protein ID: WP_057022003.1
• Coordinates: 1744169..1744408 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K01_RS08010	1739336..1740352	-	1017	WP_057021998.1	DUF4917 family protein	-
C4K01_RS08015	1740476..1741624	+	1149	WP_057021999.1	L-threonine dehydrogenase	-
C4K01_RS08020	1741715..1742389	+	675	WP_057022000.1	NAD(P)H-binding protein	-
C4K01_RS08025	1742413..1742901	-	489	WP_057022001.1	DMT family transporter	-
C4K01_RS08030	1742970..1743887	+	918	WP_057022002.1	LysR family transcriptional regulator	-
C4K01_RS08035	1743895..1744179	-	285	WP_082636613.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
C4K01_RS08040	1744169..1744408	-	240	WP_057022003.1	ribbon-helix-helix protein, CopG family	Antitoxin
C4K01_RS08045	1744508..1744924	+	417	WP_057022004.1	fosfomycin resistance glutathione transferase	-
C4K01_RS08050	1744972..1745613	+	642	WP_057022005.1	LysE family translocator	-
C4K01_RS08055	1745734..1746261	+	528	WP_005785958.1	DUF4142 domain-containing protein	-
C4K01_RS08060	1746317..1746742	-	426	WP_057022006.1	low affinity iron permease family protein	-
C4K01_RS08065	1746921..1747703	+	783	WP_057022007.1	GNAT family N-acetyltransferase	-
C4K01_RS08070	1747704..1748204	-	501	WP_057022008.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
C4K01_RS08075	1748304..1748615	-	312	WP_057022009.1	hypothetical protein	-
C4K01_RS08080	1748698..1749108	-	411	WP_057022010.1	type II toxin-antitoxin system HicB family antitoxin	-
C4K01_RS08085	1749131..1749313	-	183	WP_082636614.1	type II toxin-antitoxin system HicA family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11121.86 Da
• Isoelectric Point: 10.4171

>T100210 WP_082636613.1 NZ_CP027756:c1744179-1743895 [Pseudomonas synxantha]
MQIEWLRTALRNLDDEAAYIAEENPKAAHEFVQAILSGLEHVARFPAMGKEGRVPGTREWVVPRWPYIVPYRIREGRLQV
MRIFHTRRQPPKSW

Nucleotide

• Length: 285 bp

>T100210 NZ_CP027756:c1744179-1743895 [Pseudomonas synxantha]
ATGCAGATTGAGTGGCTACGGACAGCCCTGAGGAATCTTGACGATGAAGCAGCCTATATTGCCGAAGAAAACCCCAAAGC
TGCCCATGAGTTTGTCCAGGCAATTTTGAGTGGCCTTGAACATGTGGCCCGGTTCCCTGCGATGGGGAAAGAGGGCCGAG
TGCCTGGAACACGCGAGTGGGTTGTACCTCGATGGCCCTACATCGTTCCGTATCGCATTCGGGAGGGGCGACTTCAGGTA
ATGAGGATTTTTCATACTCGTCGGCAACCACCTAAATCCTGGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8651.81 Da
• Isoelectric Point: 4.5843

>AT100210 WP_057022003.1 NZ_CP027756:c1744408-1744169 [Pseudomonas synxantha]
MSVMSLRIPEDVAETLTNLAKATGRSKSFLAVDALREYLAREAWQIEEIQKALKEADAGEFATVAEVNAVAAKWRANAD

Nucleotide

• Length: 240 bp

>AT100210 NZ_CP027756:c1744408-1744169 [Pseudomonas synxantha]
ATGTCTGTTATGTCCCTGCGTATACCGGAAGACGTCGCCGAGACACTTACCAATCTTGCCAAGGCTACCGGTCGCAGCAA
ATCCTTTCTCGCCGTTGATGCGTTACGTGAATACTTGGCGCGTGAAGCCTGGCAAATCGAAGAAATACAAAAAGCACTGA
AGGAAGCGGATGCGGGTGAATTCGCCACGGTTGCCGAGGTAAACGCTGTCGCTGCTAAATGGCGCGCCAATGCAGATTGA