Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4145072..4145636 Replicon chromosome
Accession NZ_CP027755
Organism Pseudomonas synxantha strain 2-79

Toxin (Protein)


Gene name relE Uniprot ID A0A0D0TCX9
Locus tag C4K02_RS18710 Protein ID WP_043049586.1
Coordinates 4145349..4145636 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D0RPF8
Locus tag C4K02_RS18705 Protein ID WP_043049587.1
Coordinates 4145072..4145359 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K02_RS18670 4140826..4141305 - 480 WP_043049591.1 hypothetical protein -
C4K02_RS18675 4142137..4142445 + 309 WP_043049590.1 lipoprotein -
C4K02_RS18680 4143317..4143553 - 237 WP_043049589.1 helix-turn-helix domain-containing protein -
C4K02_RS18685 4143652..4144077 + 426 WP_043049588.1 hypothetical protein -
C4K02_RS18690 4144129..4144387 - 259 Protein_3599 transcriptional regulator -
C4K02_RS18695 4144465..4144665 - 201 WP_124421747.1 hypothetical protein -
C4K02_RS18705 4145072..4145359 + 288 WP_043049587.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C4K02_RS18710 4145349..4145636 + 288 WP_043049586.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K02_RS18715 4145947..4146516 - 570 WP_052501146.1 hypothetical protein -
C4K02_RS18720 4146771..4147289 - 519 WP_052501145.1 hypothetical protein -
C4K02_RS18725 4147340..4147576 - 237 WP_043049585.1 hypothetical protein -
C4K02_RS18730 4147615..4147746 - 132 WP_094030725.1 YHYH domain-containing protein -
C4K02_RS18735 4148073..4148294 + 222 WP_043049584.1 hypothetical protein -
C4K02_RS18740 4148293..4148715 + 423 Protein_3608 integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4139469..4160276 20807


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10931.82 Da        Isoelectric Point: 10.3662

>T100207 WP_043049586.1 NZ_CP027755:4145349-4145636 [Pseudomonas synxantha]
MGVEYEVEWDPKALKELRKLDGTIRLQFLKKLQERQAGPRVAGDALHGMKDCYKIKLRGAGYRLVYRVEGERIVILVLAV
GKRERSSVYEQAGKR

Download         Length: 288 bp

>T100207 NZ_CP027755:4145349-4145636 [Pseudomonas synxantha]
ATGGGCGTTGAGTACGAGGTTGAATGGGATCCGAAGGCGCTGAAAGAACTGCGAAAACTCGACGGCACAATCCGCCTCCA
GTTTCTGAAAAAGCTCCAGGAGCGGCAGGCCGGACCTCGGGTGGCAGGCGATGCACTCCACGGCATGAAGGATTGCTACA
AGATCAAATTGCGCGGCGCCGGCTACCGGCTGGTGTATCGCGTTGAGGGTGAGCGAATAGTTATCCTGGTGCTGGCTGTC
GGCAAGCGAGAGCGCAGTTCGGTGTACGAGCAGGCAGGGAAACGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10267.78 Da        Isoelectric Point: 4.5972

>AT100207 WP_043049587.1 NZ_CP027755:4145072-4145359 [Pseudomonas synxantha]
MQNILADVAVSVSELKKNPSSVLSSANGLPVAVLNHNRVMGYMVPANVYEAMVERLDELELVHLVKGRLDAKETPVRVSL
DDLIGEAEADIANGR

Download         Length: 288 bp

>AT100207 NZ_CP027755:4145072-4145359 [Pseudomonas synxantha]
ATGCAAAATATTCTGGCTGATGTGGCGGTGAGCGTTTCCGAACTCAAGAAGAACCCCTCCTCCGTCTTGAGCAGTGCCAA
CGGCCTGCCCGTGGCCGTACTGAACCACAACCGCGTAATGGGCTACATGGTTCCGGCAAATGTCTACGAAGCGATGGTAG
AGCGCCTGGACGAACTGGAGCTGGTTCACCTGGTCAAGGGTCGTCTCGATGCCAAGGAAACACCTGTTCGAGTATCTCTC
GACGATTTGATTGGCGAGGCCGAGGCAGACATAGCCAATGGGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D0TCX9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D0RPF8

References