Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6209052..6209641 Replicon chromosome
Accession NZ_CP027753
Organism Pseudomonas chlororaphis strain B25

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag C4K04_RS28490 Protein ID WP_124322503.1
Coordinates 6209342..6209641 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C4K04_RS28485 Protein ID WP_009045810.1
Coordinates 6209052..6209345 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K04_RS28465 6204599..6205762 - 1164 WP_124322500.1 acyltransferase -
C4K04_RS28470 6205957..6207147 - 1191 WP_124322501.1 serine hydrolase -
C4K04_RS28475 6207274..6208161 + 888 WP_009051074.1 LysR family transcriptional regulator -
C4K04_RS28480 6208544..6208936 + 393 WP_124322502.1 hypothetical protein -
C4K04_RS28485 6209052..6209345 - 294 WP_009045810.1 putative addiction module antidote protein Antitoxin
C4K04_RS28490 6209342..6209641 - 300 WP_124322503.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K04_RS28495 6209812..6210261 + 450 WP_124322504.1 DUF3828 domain-containing protein -
C4K04_RS28500 6210286..6211296 - 1011 WP_206429860.1 zinc-binding dehydrogenase -
C4K04_RS28505 6211354..6211653 - 300 WP_009051080.1 ArsR family transcriptional regulator -
C4K04_RS28510 6211718..6212808 - 1091 Protein_5572 nitrite reductase, copper-containing -
C4K04_RS28515 6213034..6213276 + 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
C4K04_RS28520 6213273..6214160 + 888 WP_124322506.1 (2E,6E)-farnesyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11260.98 Da        Isoelectric Point: 10.1871

>T100193 WP_124322503.1 NZ_CP027753:c6209641-6209342 [Pseudomonas chlororaphis]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQQCGLQLVILLCGGDKS
RQSRDTELAKYLARRWSRS

Download         Length: 300 bp

>T100193 NZ_CP027753:c6209641-6209342 [Pseudomonas chlororaphis]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATTGC
TGCGCGGATTTTTCGCCTGGCCAACGGCCTTGCCGGGGATGTGTCCCCGGTGGGCGAAGGCGTCAGTGAGTTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGTGCGGCCTGCAACTCGTCATCCTGTTGTGCGGCGGCGACAAGAGT
CGCCAGAGCCGCGATACCGAACTGGCCAAATACCTGGCCCGTCGTTGGAGTCGATCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10444.96 Da        Isoelectric Point: 5.6642

>AT100193 WP_009045810.1 NZ_CP027753:c6209345-6209052 [Pseudomonas chlororaphis]
MNEPLFDYDPATALRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSEKGNPTLKTLLA
VMRALGLDMTARVHGAS

Download         Length: 294 bp

>AT100193 NZ_CP027753:c6209345-6209052 [Pseudomonas chlororaphis]
ATGAACGAACCGCTATTCGACTATGACCCCGCCACGGCCTTGCGCGACCCGCAAGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCGTTCAGTGAAAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGCGCCCTGGGGCTGGATATGACGGCGCGGGTGCATGGGGCGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References