Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2460908..2461493 Replicon chromosome
Accession NZ_CP027752
Organism Pseudomonas chlororaphis subsp. aureofaciens strain ChPhzTR38

Toxin (Protein)


Gene name PumA Uniprot ID A0A7S5HMS4
Locus tag C4K05_RS11305 Protein ID WP_016705075.1
Coordinates 2461200..2461493 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A8A9ZIA4
Locus tag C4K05_RS11300 Protein ID WP_009048177.1
Coordinates 2460908..2461198 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K05_RS11290 2458420..2459802 + 1383 WP_009048175.1 efflux transporter outer membrane subunit -
C4K05_RS11295 2459921..2460508 + 588 WP_028682910.1 hypothetical protein -
C4K05_RS11300 2460908..2461198 - 291 WP_009048177.1 putative addiction module antidote protein Antitoxin
C4K05_RS11305 2461200..2461493 - 294 WP_016705075.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K05_RS11310 2461728..2463122 - 1395 WP_053268635.1 VOC family protein -
C4K05_RS11315 2463387..2464511 + 1125 WP_041988396.1 diguanylate cyclase -
C4K05_RS11320 2464605..2465849 + 1245 WP_124301305.1 M20/M25/M40 family metallo-hydrolase -
C4K05_RS11325 2466088..2466486 + 399 WP_110175421.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 10699.27 Da        Isoelectric Point: 10.0959

>T100185 WP_016705075.1 NZ_CP027752:c2461493-2461200 [Pseudomonas chlororaphis subsp. aureofaciens]
MDYEILQTTVFAQWHTTLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNTGAGYRLYFTVRGNTLIVLLLGGDK
SSQPADICQARSLAKEF

Download         Length: 294 bp

>T100185 NZ_CP027752:c2461493-2461200 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGGATTACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCACACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCGTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATACAGGCGCCGGCTACCGCCTCTATTTCACGGTTCGCGGCAATACCCTCATCGTCCTGCTGCTGGGTGGCGACAAG
TCCAGCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10279.84 Da        Isoelectric Point: 8.0096

>AT100185 WP_009048177.1 NZ_CP027752:c2461198-2460908 [Pseudomonas chlororaphis subsp. aureofaciens]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKTTGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT100185 NZ_CP027752:c2461198-2460908 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGACGAACTGATCCGCGCCCTGGGCCACGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGACCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCTTTTGCCCCGGGGGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGCTGTGCACCACCGTGCCCCGAGGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7S5HMS4


Antitoxin

Source ID Structure
AlphaFold DB A0A8A9ZIA4

References