Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2352158..2352743 Replicon chromosome
Accession NZ_CP027751
Organism Pseudomonas chlororaphis subsp. aureofaciens strain ChPhzTR18

Toxin (Protein)


Gene name PumA Uniprot ID A0A7S5HMS4
Locus tag C4K06_RS10775 Protein ID WP_016705075.1
Coordinates 2352450..2352743 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A8A9ZIA4
Locus tag C4K06_RS10770 Protein ID WP_009048177.1
Coordinates 2352158..2352448 (-) Length 97 a.a.

Genomic Context


C4K06_RS10760C4K06_RS10765C4K06_RS10785C4K06_RS10770C4K06_RS10775C4K06_RS10780C4K06_RS10790C4K06_RS10795
Location: 2349670..2351052 (1383 bp)
Type: Others
Protein ID: WP_009048175.1
Location: 2351171..2351758 (588 bp)
Type: Others
Protein ID: WP_028682910.1
Location: 2354637..2355761 (1125 bp)
Type: Others
Protein ID: WP_041988396.1
Location: 2352158..2352448 (291 bp)
Type: Antitoxin
Protein ID: WP_009048177.1
Location: 2352450..2352743 (294 bp)
Type: Toxin
Protein ID: WP_016705075.1
Location: 2352978..2354372 (1395 bp)
Type: Others
Protein ID: WP_053268635.1
Location: 2356034..2356459 (426 bp)
Type: Others
Protein ID: WP_124303536.1
Location: 2356473..2357540 (1068 bp)
Type: Others
Protein ID: WP_124303538.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4K06_RS107602349670..2351052+1383WP_009048175.1efflux transporter outer membrane subunit-
C4K06_RS107652351171..2351758+588WP_028682910.1hypothetical protein-
C4K06_RS107702352158..2352448-291WP_009048177.1putative addiction module antidote proteinAntitoxin
C4K06_RS107752352450..2352743-294WP_016705075.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C4K06_RS107802352978..2354372-1395WP_053268635.1VOC family protein-
C4K06_RS107852354637..2355761+1125WP_041988396.1diguanylate cyclase-
C4K06_RS107902356034..2356459-426WP_124303536.1tail fiber assembly protein-
C4K06_RS107952356473..2357540-1068WP_124303538.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2352158..239114938991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 10699.27 Da        Isoelectric Point: 10.0959

>T100177 WP_016705075.1 NZ_CP027751:c2352743-2352450 [Pseudomonas chlororaphis subsp. aureofaciens]
MDYEILQTTVFAQWHTTLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNTGAGYRLYFTVRGNTLIVLLLGGDK
SSQPADICQARSLAKEF

Download         Length: 294 bp

>T100177 NZ_CP027751:c2352743-2352450 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGGATTACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCACACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCGTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATACAGGCGCCGGCTACCGCCTCTATTTCACGGTTCGCGGCAATACCCTCATCGTCCTGCTGCTGGGTGGCGACAAG
TCCAGCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10279.84 Da        Isoelectric Point: 8.0096

>AT100177 WP_009048177.1 NZ_CP027751:c2352448-2352158 [Pseudomonas chlororaphis subsp. aureofaciens]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKTTGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT100177 NZ_CP027751:c2352448-2352158 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGACGAACTGATCCGCGCCCTGGGCCACGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGACCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCTTTTGCCCCGGGGGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGCTGTGCACCACCGTGCCCCGAGGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A7S5HMS4


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A8A9ZIA4

References