Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1529475..1530003 Replicon chromosome
Accession NZ_CP027750
Organism Pseudomonas chlororaphis subsp. aureofaciens strain ChPhzS24

Toxin (Protein)


Gene name relE Uniprot ID A0A7S5LMJ4
Locus tag C4K07_RS06985 Protein ID WP_038581545.1
Coordinates 1529475..1529774 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7S5HLJ1
Locus tag C4K07_RS06990 Protein ID WP_038581543.1
Coordinates 1529764..1530003 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K07_RS06965 1525390..1526172 - 783 WP_097302274.1 aldolase -
C4K07_RS06970 1526332..1526874 + 543 WP_007922237.1 XRE family transcriptional regulator -
C4K07_RS06975 1527076..1528095 - 1020 WP_009047445.1 DUF4917 family protein -
C4K07_RS06980 1528253..1529401 + 1149 WP_124301212.1 L-threonine dehydrogenase -
C4K07_RS06985 1529475..1529774 - 300 WP_038581545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K07_RS06990 1529764..1530003 - 240 WP_038581543.1 ribbon-helix-helix protein, CopG family Antitoxin
C4K07_RS06995 1530140..1530556 + 417 WP_016702100.1 fosfomycin resistance glutathione transferase -
C4K07_RS07000 1530684..1531322 + 639 WP_016702101.1 LysE family translocator -
C4K07_RS07005 1531434..1532774 + 1341 WP_016702102.1 sensor domain-containing diguanylate cyclase -
C4K07_RS07010 1532914..1533437 + 524 Protein_1362 DUF4142 domain-containing protein -
C4K07_RS07015 1533531..1534421 - 891 WP_041988760.1 phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-82)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11487.13 Da        Isoelectric Point: 10.8916

>T100168 WP_038581545.1 NZ_CP027750:c1529774-1529475 [Pseudomonas chlororaphis subsp. aureofaciens]
MHVEWLRSALKNLDDEAAYIAQDSPQAAAEFVKAILSSIQHLSRFPASGREGRLPGTREWVVPNRPYLIPYRVRQGRLQI
LRIFHTRRLPPAGWQDDRQ

Download         Length: 300 bp

>T100168 NZ_CP027750:c1529774-1529475 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGCACGTTGAGTGGCTGCGCAGCGCCCTCAAGAACCTCGATGACGAAGCCGCCTACATTGCACAGGACAGTCCTCAGGC
CGCCGCGGAATTCGTCAAAGCCATCCTGAGTAGCATTCAACACCTGAGCCGTTTTCCTGCCAGTGGTCGCGAAGGTCGCC
TGCCCGGTACCCGGGAGTGGGTGGTCCCCAATCGTCCTTACCTGATCCCCTACCGCGTACGTCAGGGACGCCTGCAGATA
CTGCGGATTTTCCACACCCGGCGCTTGCCGCCTGCCGGTTGGCAAGACGACCGCCAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8648.73 Da        Isoelectric Point: 4.5535

>AT100168 WP_038581543.1 NZ_CP027750:c1530003-1529764 [Pseudomonas chlororaphis subsp. aureofaciens]
MSVMSLRLPDDVADTLAHLAKATGRSKSFLAVDALREYLAREAWQINEIQKALTEAEAGDFASAEELDGVLNKWTGNAR

Download         Length: 240 bp

>AT100168 NZ_CP027750:c1530003-1529764 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGTCCGTCATGTCCTTGCGCCTGCCCGATGATGTTGCCGATACCCTGGCTCACTTGGCCAAGGCGACAGGCCGCAGCAA
GTCATTCCTCGCTGTGGATGCACTGAGAGAATATCTGGCCCGCGAAGCCTGGCAAATCAACGAGATCCAGAAAGCCCTGA
CTGAAGCAGAGGCAGGCGACTTCGCCAGCGCCGAAGAGCTGGATGGCGTACTCAACAAATGGACTGGCAATGCACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S5LMJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7S5HLJ1

References