Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 311414..312027 Replicon chromosome
Accession NZ_CP027749
Organism Pseudomonas chlororaphis subsp. aureofaciens strain ChPhzTR39

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag C4K08_RS01365 Protein ID WP_009041685.1
Coordinates 311414..311596 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PT90
Locus tag C4K08_RS01370 Protein ID WP_009046450.1
Coordinates 311626..312027 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K08_RS01340 306595..308559 + 1965 WP_164485207.1 choline transporter BetT -
C4K08_RS01345 308675..308932 - 258 WP_009046444.1 hypothetical protein -
C4K08_RS01350 308985..309473 - 489 WP_016702554.1 DoxX family protein -
C4K08_RS01355 309530..310270 - 741 WP_009046448.1 SDR family oxidoreductase -
C4K08_RS01360 310399..311289 + 891 WP_038630364.1 LysR family transcriptional regulator -
C4K08_RS01365 311414..311596 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K08_RS01370 311626..312027 + 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K08_RS01375 312596..313633 + 1038 WP_016702559.1 L-glyceraldehyde 3-phosphate reductase -
C4K08_RS01380 313763..314191 - 429 WP_023970008.1 type II toxin-antitoxin system VapC family toxin -
C4K08_RS01385 314188..314433 - 246 WP_016702561.1 plasmid stabilization protein -
C4K08_RS01390 314573..315412 - 840 WP_009046454.1 taurine dioxygenase -
C4K08_RS01395 315639..316478 - 840 WP_038630365.1 taurine ABC transporter permease TauC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T100159 WP_009041685.1 NZ_CP027749:311414-311596 [Pseudomonas chlororaphis subsp. aureofaciens]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

>T100159 NZ_CP027749:311414-311596 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAATA
CAAGCATCTGCACAAGCCGGGACGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14596.44 Da        Isoelectric Point: 4.9133

>AT100159 WP_009046450.1 NZ_CP027749:311626-312027 [Pseudomonas chlororaphis subsp. aureofaciens]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT100159 NZ_CP027749:311626-312027 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCTGCGCAAGCCTTCGAGAATGTGAAAGAGGCCCTTTCGCTGCATTATGAAGGCCTGGTCGCCGATG
GTGAGCCGCTGCCCCAGGTGCATGAGGTCGACGTGCATATCGACAATCCTGATTACGCCGGTGGCGTGTGGGGCGTGATC
GAGTTCGACATCACGCCTTACTTCGGCAAGGCGGTGCGTTTCAATGCGACGTTGCCGGAGCAACTGTTGGAGCGCATCGA
CCAGACGGTGAAGCGCGACCAGCGCTACCGTTCGCGCTCGGGCTTTCTCGCGGCAGCGGCATTGCGCGAACTCTCCGCCT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A554PT90

References