Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 320716..321329 Replicon chromosome
Accession NZ_CP027747
Organism Pseudomonas chlororaphis subsp. aureofaciens strain 66

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag C4K10_RS01400 Protein ID WP_009041685.1
Coordinates 320716..320898 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PT90
Locus tag C4K10_RS01405 Protein ID WP_009046450.1
Coordinates 320928..321329 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K10_RS01375 315897..317861 + 1965 WP_164485207.1 choline transporter BetT -
C4K10_RS01380 317977..318234 - 258 WP_009046444.1 hypothetical protein -
C4K10_RS01385 318287..318775 - 489 WP_016702554.1 DoxX family protein -
C4K10_RS01390 318832..319572 - 741 WP_009046448.1 SDR family oxidoreductase -
C4K10_RS01395 319701..320591 + 891 WP_038630364.1 LysR family transcriptional regulator -
C4K10_RS01400 320716..320898 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K10_RS01405 320928..321329 + 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K10_RS01410 321899..322936 + 1038 WP_124339462.1 L-glyceraldehyde 3-phosphate reductase -
C4K10_RS01415 323066..323494 - 429 WP_023970008.1 type II toxin-antitoxin system VapC family toxin -
C4K10_RS01420 323491..323736 - 246 WP_028683845.1 plasmid stabilization protein -
C4K10_RS01425 323876..324715 - 840 WP_124339463.1 taurine dioxygenase -
C4K10_RS01430 324952..325791 - 840 WP_081362977.1 taurine ABC transporter permease TauC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T100151 WP_009041685.1 NZ_CP027747:320716-320898 [Pseudomonas chlororaphis subsp. aureofaciens]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

>T100151 NZ_CP027747:320716-320898 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAATA
CAAGCATCTGCACAAGCCGGGACGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14596.44 Da        Isoelectric Point: 4.9133

>AT100151 WP_009046450.1 NZ_CP027747:320928-321329 [Pseudomonas chlororaphis subsp. aureofaciens]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT100151 NZ_CP027747:320928-321329 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCTGCGCAAGCCTTCGAGAATGTGAAAGAGGCCCTGTCGCTGCATTACGAAGGCCTGGTCGCCGATG
GTGAGCCGCTGCCCCAGGTGCATGAGGTCGACGTGCATATCGACAATCCTGATTACGCCGGTGGCGTGTGGGGGGTGATC
GAGTTCGACATCACGCCTTACTTCGGCAAGGCGGTGCGTTTCAATGCGACGTTGCCGGAGCAACTGTTGGAGCGCATCGA
CCAGACGGTGAAGCGCGACCAGCGCTACCGTTCGCGCTCGGGCTTTCTCGCGGCAGCGGCATTGCGCGAACTCTCCGCCT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A554PT90

References