Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type II Classification (family/domain) PanAT/-
Location 29350..30754 Replicon chromosome
Accession NZ_CP006764
Organism Corynebacterium doosanense CAU 212 = DSM 45436 strain CAU 212(T)

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag CDOO_RS11570 Protein ID WP_018022804.1
Coordinates 2363610..2364023 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A097IIB1
Locus tag CDOO_RS11575 Protein ID WP_018022803.1
Coordinates 2364023..2364589 (-) Length 189 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDOO_RS00125 (CDOO_00130) 26533..28005 - 1473 WP_018022352.1 phytoene desaturase -
CDOO_RS00130 (CDOO_00135) 28002..28793 - 792 WP_018022351.1 phytoene/squalene synthase family protein -
CDOO_RS00135 (CDOO_00140) 28804..29076 - 273 WP_018022350.1 aldehyde dehydrogenase family protein -
CDOO_RS00140 (CDOO_00145) 29236..30273 + 1038 WP_018022349.1 iron-siderophore ABC transporter substrate-binding protein -
CDOO_RS00145 (CDOO_00150) 30396..31316 + 921 WP_155861363.1 iron ABC transporter permease -
CDOO_RS00150 (CDOO_00155) 31376..32320 + 945 WP_081610373.1 iron ABC transporter permease -
CDOO_RS00155 (CDOO_00160) 32317..33123 + 807 WP_018022346.1 ABC transporter ATP-binding protein -
CDOO_RS00160 (CDOO_00165) 33123..34028 + 906 WP_018022345.1 siderophore-interacting protein -
CDOO_RS00165 (CDOO_00170) 34025..34879 - 855 WP_018022344.1 hypothetical protein -
CDOO_RS00170 (CDOO_00175) 35019..35540 + 522 WP_018022343.1 peptidylprolyl isomerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-127)

Antitoxin

(23-117)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 14944.07 Da        Isoelectric Point: 4.5967

>T10015 WP_018022804.1 NZ_CP006764:c2364023-2363610 [Corynebacterium doosanense CAU 212 = DSM 45436]
MDREQVMVSLLVREALEINRGCASRDEPFAGFGLRDEAALRSAIGAVFQSVIGQPAYPDVYSRGAALLIKVAKAHAFVDG
NKRTAFLLCVTYLGIGEISISPQCPQEAIDFVERVTKSDEDQGDLIRIAASQLLEWS

Download         Length: 414 bp

>T10015 NZ_CP006764:c2364023-2363610 [Corynebacterium doosanense CAU 212 = DSM 45436]
ATGGACCGGGAACAGGTCATGGTGTCTCTTTTGGTGCGGGAGGCACTCGAGATAAACCGGGGTTGCGCGTCGCGGGATGA
ACCCTTCGCTGGGTTCGGTTTGCGTGACGAAGCAGCGCTCCGAAGCGCAATTGGGGCGGTATTCCAATCTGTCATCGGAC
AGCCTGCCTACCCGGACGTCTACAGCCGTGGAGCTGCCCTGCTCATTAAAGTTGCCAAGGCGCACGCGTTCGTCGACGGA
AACAAAAGGACGGCCTTCCTGCTCTGCGTGACGTACCTCGGTATTGGGGAAATAAGCATTAGCCCGCAATGCCCTCAGGA
GGCGATTGATTTCGTCGAGAGAGTTACAAAGTCCGACGAGGACCAGGGAGATCTCATCCGAATCGCAGCGAGCCAACTTC
TGGAATGGAGTTAG

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21000.57 Da        Isoelectric Point: 4.8708

>AT10015 WP_018022803.1 NZ_CP006764:c2364589-2364023 [Corynebacterium doosanense CAU 212 = DSM 45436]
MATIFDVAQSIVQLRPGLTKIELYKLCYFAQGWHSTWVGQPLFTQPMEAWKYGPVSPELRQHSRSTGNRIDSIDTGSSDN
LGDYERELIANVVEFYEGVAAFGADGLSDQSHGPAWQNARGDLPPEAACSVVIQQTDIRKEFTQRMWGEDPKPDAPATLP
PFSADELSRVRRQAEITHREVLRGLALI

Download         Length: 567 bp

>AT10015 NZ_CP006764:c2364589-2364023 [Corynebacterium doosanense CAU 212 = DSM 45436]
ATGGCAACCATTTTCGATGTCGCTCAGAGCATCGTCCAGCTTCGGCCTGGGCTGACCAAAATCGAACTTTACAAGCTCTG
CTACTTCGCCCAAGGTTGGCATTCCACGTGGGTTGGCCAGCCGCTGTTCACGCAACCCATGGAAGCGTGGAAGTACGGCC
CGGTAAGTCCGGAATTGCGCCAGCACAGTCGCTCGACCGGCAATCGCATCGACTCCATCGACACTGGAAGCTCGGACAAC
CTTGGCGATTATGAGCGTGAGCTTATCGCGAACGTTGTTGAATTCTATGAGGGTGTGGCAGCTTTCGGGGCAGACGGGTT
GTCCGATCAAAGCCACGGTCCTGCATGGCAAAACGCGCGCGGAGATCTTCCGCCCGAGGCGGCCTGCTCGGTGGTCATTC
AGCAGACCGATATCCGCAAGGAATTTACCCAGCGGATGTGGGGTGAAGATCCCAAGCCGGATGCCCCTGCGACTCTGCCC
CCGTTTAGTGCTGATGAACTTTCCCGAGTCCGTCGACAGGCGGAGATCACGCACCGTGAGGTACTGCGAGGCCTTGCGCT
CATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A097IIB1

References


(1) Tatsuaki Kurata et al. (2022) A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains. Proceedings of The National Academy of Sciences of The United States of America 119(6):e2102212119. [PubMed:35121656] experimental


experimental experimental literature